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Cloud computing represents a promising computing paradigm where computing resources have to be allocated to software for their execution. Self-manageable Cloud infrastructures are required to achieve that level of flexibility on one hand, and to comply to users' requirements specified by means of Service Level Agreements (SLAs) on the other. Such(More)
Quality of service (QoS) can be a critical element for achieving the business goals of a service provider, for the acceptance of a service by the user, or for guaranteeing service characteristics in a composition of services, where a service is defined as either a software or a software-support (i.e., infrastructural) service which is available on any type(More)
This study tested the hypothesis that the induction of autophagy by producing therapeutic amounts of endoplasmic reticulum (ER) stress in the heart before an ischemic insult would ameliorate/reduce subsequent lethal myocardial ischemic/reperfusion (I/R) injury (similar to ischemic preconditioning). A dose-response study with both tunicamycin and(More)
BACKGROUND Growing evidence exists for soluble Angiotensin Converting Enzyme-2 (sACE2) as a biomarker in definitive heart failure (HF), but there is little information about changes in sACE2 activity in hypertension with imminent heart failure and in reverse remodeling. METHODS, FINDINGS Patients with systolic HF (NYHAII-IV, enrolled for cardiac(More)
Cloud computing is a newly emerged research infrastructure that builds on the latest achievements of diverse research areas, such as Grid computing, Service-oriented computing, business processes and virtualization. In this paper we present an architecture for SLA-based resource virtualization that provides an extensive solution for executing user(More)
The present study examined the efficacy of using longevinex, a commercially available resveratrol formulation, to lower blood cholesterol in hypercholesteromic rabbits. New Zealand white rabbits were randomly divided into two groups (n = 6 per group), one group was given high cholesterol diet for 3 months while the other group fed regular diet served as(More)
Grid computing has gone through some generations and as a result only a few widely used middleware architectures remain. Using the tools of these middlewares, various resource brokers have been developed to automate job submission over different grids. Most of the present brokers operate only on a single grid infrastructure, where they have been developed.(More)