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Signal Integration of IFN-I and IFN-II With TLR4 Involves Sequential Recruitment of STAT1-Complexes and NFκB to Enhance Pro-inflammatory Transcription
TLDR
Co-binding of STAT1-containing transcription factor complexes and NFκB, activated by IFN-I or IFN -II together with LPS, provides a platform for robust transcriptional activation of pro-inflammatory genes. Expand
Specific enhancer selection by IRF3, IRF5 and IRF9 is determined by ISRE half-sites, 5′ and 3′ flanking bases, collaborating transcription factors and the chromatin environment in a combinatorial
TLDR
This study contributes to the understanding of how IRF members, which bind overlapping sets of DNA sequences, can initiate signal-dependent responses without activating superfluous or harmful programmes. Expand