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Acetyl and butyrylcholinesterase-inhibiting triterpenoid alkaloids from Buxus papillosa.
Three triterpenoid alkaloids, buxakashmiramine [(20S)-20-dimethylamino-4',6'-dimethoxy-5'-hydroxybenzoylamino-3beta-methyl-buxan-31-ol] (1), buxakarachiamineExpand
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Presence of antispasmodic, antidiarrheal, antisecretory, calcium antagonist and acetylcholinesterase inhibitory steroidal alkaloids in Sarcococca saligna.
The aim of this investigation was to see if the crude extract of Sarcococca saligna (Ss.Cr) contains chemicals with gut function inhibitory activity by using in vitro and in vivo assays. Ss.Cr causedExpand
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Structural basis of acetylcholinesterase inhibition by triterpenoidal alkaloids.
Acetylcholinesterase plays a crucial role in the metabolism of neurotransmitter, acetylcholine. Inhibition of Torpedo californica acetylcholinesterase by triterpenoidal alkaloids buxamine-B (1) andExpand
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Isolation and immunomodulatory properties of a flavonoid, casticin from Vitex agnus‐castus
Casticin (1), a flavonoid isolated from the aerial parts of Vitex agnus‐castus, was found to be a potent immunomodulatory and cytotoxic compound. The activity was tested in vitro forExpand
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New Cholinesterase‐Inhibiting Triterpenoid Alkaloids from Buxus hyrcana
The current phytochemical investigation on Buxus hyrcana Pojark. has resulted in the isolation of the triterpenoid alkaloids 1–10. The structures of five new alkaloids, hyrcanone (1), hyrcanol (2),Expand
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Alkaloids of Aconitum laeve and their anti-inflammatory antioxidant and tyrosinase inhibition activities.
A lycoctonine-type norditerpenoid alkaloid, swatinine (1), along with four known norditerpenoid alkaloids, delphatine (3), lappaconitine (4), puberanine (5), and N-acetylsepaconitine (6), and wereExpand
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Kinetics and structure-activity relationship studies on pregnane-type steroidal alkaloids that inhibit cholinesterases.
The mechanism of inhibition of acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BChE, EC 3.1.1.8) enzymes by 23 pregnane-type alkaloids isolated from the Sarcococca saligna wasExpand
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Juliflorine: a potent natural peripheral anionic-site-binding inhibitor of acetylcholinesterase with calcium-channel blocking potential, a leading candidate for Alzheimer's disease therapy.
The alkaloid juliflorine (1) from Prosopis juliflora inhibited acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BChE, EC 3.1.1.8) enzymes in a concentration-dependent fashion withExpand
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Antifungal diterpenoid alkaloids from Delphinium denudatum.
The roots of Delphinium denudatum have yielded a new diterpenoid alkaloid, 8-acetylheterophyllisine (1), in addition to the known alkaloids vilmorrianone (2), panicutine (3), denudatine (4),Expand
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Antiinflammatory and lipoxygenase inhibitory compounds from vitex agnus‐castus
Several secondary metabolites, artemetin (1), casticin (2), 3,3′‐dihydroxy‐5,6,7,4′‐tetramethoxy flavon (3), penduletin (4), methyl 4‐hydroxybenzoate (5), p‐hydroxybenzoic acid (6), methylExpand
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