Atsushi Shionoiri

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It is well established that activated vitamin D(3) affects bone metabolism and its bone fracture reducing effect is prominent considering relatively weak effect on increase of bone mineral density. The risk of osteoporotic bone fracture generally correlates with bone mineral density. On the other hand, fall is a major cause of bone fracture in the elderly(More)
ED-71 is a vitamin D analog which was designed to have prominent effect on bone tissue. ED-71 has a hydroxypropoxy residue at the 2beta position and binds to the vitamin D receptor with one eighth affinity compared with original 1alpha,25-dihydroxyvitamin D(3). ED-71 has a longer half life than 1alpha,25-dihydroxyvitamin D(3) due to twice as high affinity(More)
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