Atsushi Ogiwara

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Although postoperative adjuvant chemotherapy (PAC) with uracil-tegafur significantly improves the prognosis of patients with stage I lung adenocarcinoma, subset analysis has revealed that only 11.5% of patients with stage IB derive actual benefit from such therapy. Therefore, it is extremely important to identify patients for whom adjuvant chemotherapy will(More)
Interstitial lung disease (ILD) events have been reported in Japanese non-small-cell lung cancer (NSCLC) patients receiving EGFR tyrosine kinase inhibitors. We investigated proteomic biomarkers for mechanistic insights and improved prediction of ILD. Blood plasma was collected from 43 gefitinib-treated NSCLC patients developing acute ILD (confirmed by(More)
UNLABELLED We developed new software environment for the metabolome analysis of large-scale multiple reaction monitoring (MRM) assays. It supports the data format of four major mass spectrometer vendors and mzML common data format. This program provides a process pipeline from the raw-format import to high-dimensional statistical analyses. The novel aspect(More)
The sequencing of the whole Bacillus subtilis genome has been completed. The genome contains about 4,000 ORFs, and information of these ORFs are stored in BSORF database, which was formerly reported as a database of Japanese groups' achievements [1, 2]. Using the complete genome database, we performed comprehensive sequence analyses based on the sequence(More)
MOTIVATION Peptide-sequencing methods by mass spectrum use the following two approaches: database searching and de novo sequencing. The database-searching approach is convenient; however, in cases wherein the corresponding sequences are not included in the databases, the exact identification is difficult. On the other hand, in the case of de novo(More)
Based on theoretically calculated comprehensive lipid libraries, in lipidomics as many as 1000 multiple reaction monitoring (MRM) transitions can be monitored for each single run. On the other hand, lipid analysis from each MRM chromatogram requires tremendous manual efforts to identify and quantify lipid species. Isotopic peaks differing by up to a few(More)
The identification of metabolites in drug discovery is important. At present, radioisotopes and mass spectrometry are both widely used. However, rapid and comprehensive identification is still laborious and difficult. In this study, we developed new analytical software and employed a stable isotope as a tool to identify drug metabolites using mass(More)
Owing to an error on the part of the authors, mistakes were made in the assignment of protein names to the peptides found as biomarkers in the above paper. The last two graphs in Figure 1 entitled 'VIM_5' (lower middle) and 'VIM_6' (lower right) should be removed. They are not vimentin-derived peptide signals. The caption of Figure 1B should also be(More)