Atsushi Miyata

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BACKGROUND The main challenge to the long-term treatment of osteoporosis with bisphosphonates has been patient adherence. The purposes of this cohort study were to investigate the 3-year outcome of alendronate treatment in postmenopausal Japanese women with osteoporosis and to identify factors that contributed to the discontinuation of alendronate(More)
Cement lines represent mineralized, extracellular matrix interfacial boundaries at which bone resorption by osteoclasts is followed by bone deposition by osteoblasts. To determine the contribution of cement lines to bone quality, the osteopetrotic c-Src mouse model—where cement lines accumulate and persist as a result of defective osteoclastic(More)
To investigate the long-term effects of c-src deficiency on skeletal and dental tissues, we examined the lower jaws and long bones of c-src gene knockout (c-src KO) mice by histological and histochemical methods. Numerous multinucleated osteoclasts were distributed throughout the mandible in 5-wk-old c-src KO mice, but by 14 wk they had almost completely(More)
A retrospective study was conducted to evaluate the outcome of treatment with alendronate (ALN) for 5 years in postmenopausal Japanese women with an increased risk of fractures. Forty postmenopausal Japanese women with osteoporosis or osteopenia and clinical risk factors for fractures (mean age: 75.4 years) were analyzed; 33 patients were treated with(More)
C-src deficiency is characterized by osteopetrosis due to impaired bone resorption by hypofunctional osteoclasts and the resultant failure of tooth eruption. In preliminary observations, we frequently encountered erupted molars in c-src deficient mice unlike in other osteopetrotic animals. Here we examine the effects of c-src deficiency on the development(More)
Preparation of liquid polyols from d-(+)-glucose (Glc) and its derivative, methyl-α-d-glucoside (m-Glc), has been studied. Direct reaction of ε-caprolactone (CL) with Glc (CL : Glc = 2 : 1–5 : 1 in weight ratio) at 150°C using tin(II) 2-ethyl hexanoate (SnEht2) (series A), in which melted Glc was suspended in CL, resulted in a dark-brown coloration of the(More)
A ring-opening polymerization of cyclic esters ε-caprolactone (CL) and/or l-lactide (LACD) was carried out in the presence of methyl-α-d-glucoside (m-Glc) as an activated substrate and tin(II) 2-ethylhexanoate (SnEht2) as a catalyst. This led to successful synthesis of an armed polyester polyol with m-Glc as the core. These polyols were characterized(More)
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