Atsushi Misonoo

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AIMS The expression of brain-derived neurotrophic factor (BDNF) may be a downstream target of a variety of antidepressant treatments, and selective serotonin reuptake inhibitors (SSRIs) are used clinically for the treatment of depression. BDNF binds to and activates tyrosine kinases receptor (TrkB) to exert its effects. TrkB, after activation by ligands,(More)
The clinical therapeutic e#ect of most antidepressant drugs only develops after several weeks of administration, but little is known about the intracellular signal transduction in neuron. Here, we examined the e#ect of chronic treatment with fluvoxamine FLV , a selective serotonin reuptake inhibitor SSRI used to treat depression, on the serine-threonine(More)
Corticotropin releasing hormone (CRH)--and norepinephrine (NE) -containing neurons in the brain are activated during stress. We previously reported a decrease in the basal level of CRH immunoreactivity in the central nucleus of the amygdala and the tyrosine hydroxylase immunoreactivity in the locus coeruleus after chronic variable stress (CVS), whereas both(More)
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