Atsushi Hashimoto

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The behavioral effects produced by MK-801 (0.4 mg/kg) were compared in mutant DAO-/- mice lacking D-amino acid oxidase activity and normal DAO+/+ mice. Mutant mice display marked diminution of stereotypy and ataxia induced by MK-801 compared to normal mice. Because the D-serine level in the brain of mutant mice is significantly higher than that of normal(More)
The behavioral effects induced by methamphetamine (5.0 mg/kg) were compared in the mutant mice lacking d-amino acid oxidase activity and normal mice. The mutant mice exhibited marked decline in the methamphetamine-induced stereotypy compared to the normal mice, whereas the mutant mice displayed a drastic augmentation in the locomotor activity evoked by(More)
This paper presents an enhanced method of testing validity of arithmetic optimization of C compilers using randomly generated programs. Its bug detection capability is improved over an existing method by 1) generating longer arithmetic expressions and 2) accommodating multiple expressions in test programs. Undefined behavior in long expressions is(More)
—This paper describes our work in computer vision to track food materials in the food preparation process. Tracking such food materials is difficult, because they are often hidden when moved by hand. Furthermore, their appearance may change in hand when they are cut or peeled. For tracking these objects in such situations, we propose a novel method that(More)
D-serine is an endogenous and obligatory coagonist for the glycine site of the N-methyl-D-aspartate receptor in the mammalian brain. D-serine is synthesized from L-serine by serine racemase; immunohistochemical studies have long been believed to indicate that serine racemase and D-serine occur predominantly in astrocytes. However, we have recently(More)
INTRODUCTION Interstitial Lung Disease (ILD) is frequently associated with Rheumatoid Arthritis (RA) as one of extra-articular manifestations. Many studies for Human Leukocyte Antigen (HLA) allelic association with RA have been reported, but few have been validated in an RA subpopulation with ILD. In this study, we investigated the association of HLA class(More)
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease. Certain HLA-DRB1 "shared-epitope" alleles are reported to be positively associated with increased RA susceptibility, whereas some of the other alleles may be negatively associated. However, studies on the latter are rare. Here, we focus on the protective effects of DRB1 alleles in(More)
We propose a method for recognizing ingredients in food preparing activity. The research for object recognition mainly focuses on only visual information; however, ingredients are difficult to recognize only by visual information because of their limited color variations and larger within-class difference than inter-class difference in shapes. In this(More)
In this paper, we provide a multimodal dataset for understanding cooking activities. To build the dataset, we instructed the subjects to perform cooking according to instructional texts shown on a display one by one. The instructional texts were generated from flow graphs, which were automatically extracted from recipes sampled from a Web site. The main(More)