Atsuo Shida

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Whether genetic influence on chemical and behavioral control of breathing is still present in adulthood was examined in 28 pairs of monozygotic (mean age, 40 +/- SD 9.9 yr) and 10 dizygotic (35 +/- 9.3 yr) twins. Mean values for hypoxic and hypercapnic ventilatory responses, threshold for perceiving added inspiratory resistance, and respiratory patterns(More)
To clarify the role of genetics in determining chemical and behavioral control of breathing, an age-, body size-, and sex ratio-matched study was conducted in 62 twins (mean age 16.4 yr, 20 pairs of monozygotic twins (MZ) and 11 pairs of dizygotic twins (DZ)] for ventilatory responses to hypoxia (A) and hypercapnia (S) along with thresholds for perception(More)
Small GTPase proteins, including RhoA, RhoB, RhoC, Rac1 and cdc42, are molecules that have significant roles in linking cell shape and cell cycle progression in cyto-skeletal arrangements and mitogenic signaling. Rho GDP dissociation inhibitor 2 (RhoGDI2) has recently been identified as a metastasis suppressor gene in models of bladder cancer. RhoGDI2 has(More)
Accurate prediction of lymph node (LN) status is crucially important for appropriate treatment planning in patients with early gastric cancer (EGC). However, consensus on patient and tumor characteristics associated with LN metastasis are yet to be reached. Through systematic search, we identified several independent variables associated with LN metastasis(More)
To differentiate genetic factors from environmental forces in determining threshold for resistance load detection (RLD), 62 healthy adolescent twins (mean age = 16 years) and 74 healthy adult twins (mean age = 34 years) were studied by the standard psychophysical technique. The zygosity was determined by blood groups, finger prints, and physical(More)
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