Atsunori Ohta

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Most acute hepatitis C virus (HCV) infections become chronic and some progress to liver cirrhosis or hepatocellular carcinoma. Standard therapy involves an interferon (IFN)-α-based regimen, and efficacy of therapy has been significantly improved by the development of protease inhibitors. However, several issues remain concerning the injectable form and the(More)
Hepatitis C virus (HCV) replicon systems enable in-depth analysis of the life cycle of HCV. However, the previously reported full-genome replicon system is unable to produce authentic virions. On the basis of these results, we constructed newly designed full-genomic replicon RNA, which is composed of the intact 5'-terminal-half RNA extending to the NS2(More)
The Candida albicans CHS4 gene complements a Saccharomyces cerevisiae sktSlchs4 mutation and is involved in chitin biosynthesis The Candicfa albicans CHS4 gene encoding chitin synthase 4 has been isolated using the Sacchammyces cerevisiae CHS4ISKT5 gene as a probe. The gene contains a 2061 bp open reading frame capable of encoding a protein of 687 amino(More)
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