Atsuko Negishi

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Adenovirus (Ad) has been extensively studied as a eukaryotic viral vector. As these vectors have evolved from first-generation vectors to vectors that contain either very few or no viral genes ("gutless" Ad), significant reductions in the host innate immune response upon infection have been observed. Regardless of these vector improvements an unknown amount(More)
Adeno-associated virus (AAV) has been widely used as a viral vector to deliver genes to animal and human tissues in gene therapy studies. Both AAV-2 and AAV-3 use cell surface heparan sulfate (HS), a highly sulfated polysaccharide, as a receptor to establish infections. In this study, we used atomic force microscopy (AFM) to investigate the interaction of(More)
Ramesh Raskar Projector-based Three Dimensional Graphics (Under the direction of Henry Fuchs and Gregory Welch) Light projectors can be arranged into electronic displays that offer large, bright, and high resolution images. However, despite their unique characteristics, projectors have been treated like any other two-dimensional display devices, e.g. CRT(More)
Advances in microscopy are not only allowing scientists to investigate phenomena at ever-decreasing scale, but also permitting sensory data beyond the visual to be gathered. This chapter describes research on middle and high school students' use of remote microscopy with a new scientific tool called the nanoManipulator, which enabled them to reach out and(More)
The impact of haptic feedback on the perception of unknown objects (10 without texture, 10 with texture, and 2 complex shapes) was examined. Using a point probe (a PHANTOM), three treatment groups of students (visual, haptic, and visual plus haptic feedback) explored a set of virtual objects. The visual treatment group observed the objects through a small(More)
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