Atle Skattebøl

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The effects of TsIV-5, a toxin isolated from the Brazilian scorpion Tityus serrulatus, on whole-cell and single-channel Na currents were determined in N18 neuroblastoma cells. In whole-cell records at a test potential of -10 mV, external application of 500 nM TsIV-5 slowed inactivation 20-fold and increased peak current by about one-third without changing(More)
Chronic administration of atropine (40-100 mg/kg, 23 days) produced a 29-33% increase in muscarinic receptors, measured by [3H]quinuclidinyl benzilate binding, in rat brain. Diisopropyl phosphorofluoridate (0.9 mg/kg, 14 days) produced a 35% decrease in muscarinic receptors. Propranolol administration (800 micrograms/kg/hr, 10 days) increased(More)
Chronic treatment of PC 12 cells with the 1,4-dihydropyridine Ca2+ channel antagonist nifedipine [5 x 10-8M/5 days] and the activator S Bay K 8644 [5 x 10-7 M/5 days] resulted in up- and down-regulation of 1,4-dihydropyridine binding site density by 29 and 24%, respectively, without change in affinity. These changes in binding site density represent(More)
K+-stimulated 45Ca2+ uptake into intact rat brain cells was biphasic, consisting of a fast first phase and a slow second phase; the latter was Na+ dependent. Cobalt and cadmium at 10(-4) and 10(-3) M produced 19-97% block of first phase 45Ca2+ uptake, but nitrendipine (to 10(-6) M) and Bay K 8644 (to 10(-6) M) were without effect on uptake and were(More)
Rats received 6-hydroxydopamine (50 mg/kg i.v.) on two successive days. After 14 days cardiac beta-adrenoceptors and Ca2+ channels were measured by radioligand binding. Ca2+ channel binding [( 3H]nitrendipine) was increased 31% with no change in affinity, and beta-adrenoceptor binding [( 3H]dihydroalprenolol) was increased 28% with no change in affinity.(More)
Fig. 1. Effects of pretreatment with Zn or Cd on Cd-induced alterations of serum levels of CHE, GPT and albumin. Rats received the following treatment 24 hr prior to the Cd challenge (1.5 mg/kg body wt, SC): A and B, a single i.p. injection of saline or Zn (8mg/kg body wt); C and D, a single S.C. injection of saline or Cd (0.3 mg/kg body wt). For comparison(More)
The effects of intrastriatal injection of kainic acid (2 microliters, 1 mg/ml) in the rat were determined. Four weeks after the lesioning, striatal dopamine receptors and 1,4-dihydropyridine sites were measured by radioligand binding with [3H]spiperone and [3H]nimodipine, respectively. Dopamine receptor and 1,4-dihydropyridine binding densities were(More)