Currently there are no uniform standard treatments for newborn suffering from cerebral hypoxia-ischemia (HI) and to find new and effective strategies for treating the HI injury remains a key direction for future research. Present study was designed to demonstrate that optimal dose (1 or 3%) of creatine monohydrate (Cr) for the treatment of neonatal HI in… (More)
BACKGROUND Present study was designed to report the effect of 2% creatine monohydrate supplementation for 8, 12 and 15 weeks on hematology and serum biochemical profile of male albino mouse following hypoxic ischemic insult on postnatal day 10. METHODS 66 Blood samples (2% creatine monohydrate supplemented (N = 34) and unsupplemented (N = 32)) were… (More)
The present study was designed to demonstrate the potential effect of CGP 35348 (GABAB receptor antagonist) on the learning, memory formation, and neuromuscular coordination in albino mouse. Mice were intrapertoneally injected with 1 mg CGP 35348/mL of distilled water/Kg body weight, while the control animals were injected with equal volume of saline… (More)
Sigmoidal growths are well approximated by the non-linear sigmoidal growth models including Richards (1959) Morgan et al (1975), Davies and Ku (1977) and Muller et al (2006) among many others. This article deals with the comparison of the nonparametric regression with the non-linear regression models in order to locate the better approximation for sigmoidal… (More)
Creatine monohydrate (Cr) is a dietary supplement known to improve cognitive functions and has positive therapeutic results under various clinical conditions. The aim of this study was to determine the effect of 2 % Cr supplementation on learning, memory formation, neuromuscular coordination, exploratory and locomotory in male albino mice following hypoxic… (More)
GABAB receptor antagonists are experimentally proved as spatial memory enhancers in mouse models but their role has not been described following hypoxic-ischemic insult. 10-day-old albino mice were subjected to Murine model of hypoxia and ischemia. Following brain damage, mice were fed on normal rodent diet till they were 13 weeks old. At this time point,… (More)
We construct a sampling algorithm to generate ordered statistics from conditional lifetime distributions by expressing the conditional distribution of ordered statistics in terms of cumulative hazard function. We use uniform spacing algorithm to generate uniform (0,1) ordered statistics in the proposed algorithm.