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Neuronal activity regulates the development and maturation of excitatory and inhibitory synapses in the mammalian brain. Several recent studies have identified signalling networks within neurons that control excitatory synapse development. However, less is known about the molecular mechanisms that regulate the activity-dependent development of GABA(More)
Charged multivesicular body protein 1A (CHMP1A; also known as chromatin-modifying protein 1A) is a member of the ESCRT-III (endosomal sorting complex required for transport-III) complex but is also suggested to localize to the nuclear matrix and regulate chromatin structure. Here, we show that loss-of-function mutations in human CHMP1A cause reduced(More)
Experience-dependent gene transcription is required for nervous system development and function. However, the DNA regulatory elements that control this program of gene expression are not well defined. Here we characterize the enhancers that function across the genome to mediate activity-dependent transcription in mouse cortical neurons. We find that the(More)
EphB receptor tyrosine kinases control multiple steps in nervous system development. However, it remains unclear whether EphBs regulate these different developmental processes directly or indirectly. In addition, given that EphBs signal through multiple mechanisms, it has been challenging to define which signaling functions of EphBs regulate particular(More)
Sensory stimuli drive the maturation and function of the mammalian nervous system in part through the activation of gene expression networks that regulate synapse development and plasticity. These networks have primarily been studied in mice, and it is not known whether there are species- or clade-specific activity-regulated genes that control features of(More)
BACKGROUND Neurogenic stress cardiomyopathy (NSC) is a known complication of aneurysmal subarachnoid hemorrhage (SAH). Detailed analyses of risk factors for its occurrence across large cohorts are relatively sparse. METHODS A consecutive group of 300 patients with aneurysmal SAH was reviewed for the presence of markers of myocardial injury, including(More)
  • Citation Soskis, H H Ho, B L Bloodgood, M A Robichaux, A N Malik, B Ataman +14 others
  • 2013
The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters. Abstract EphB receptor tyrosine kinases control multiple steps in nervous system development. However, it remains unclear whether EphBs regulate these different developmental processes directly or indirectly. In addition, as EphBs(More)
Order according to how each item relates to the main figures and tables (in parentheses), including a short description of each: Figure S1: Biochemical characterization of AMT alleles (Figure 1) Figure S2: Biochemical characterization of AMT alleles (Figure 1) Figure S5: Biochemical characterization of AMT alleles (Figure 1) Figure S3: Quantification of(More)