Aswin Seshasayee

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Complete genome sequence of uropathogenic Proteus mirabilis, a master of both adherence and motility.

Melanie M Pearson, Mohammed Sebaihia, +19 authors Harry L. T. Mobley
Journal of bacteriology
2008

The gram-negative enteric bacterium Proteus mirabilis is a frequent cause of urinary tract infections in individuals with long-term indwelling catheters or with complicated urinary tracts (e.g., due… (More)

Evidence of non-random mutation rates suggests an evolutionary risk management strategy

Iñigo Martincorena, Aswin Seshasayee, Nicholas M. Luscombe
Nature
2012

A central tenet in evolutionary theory is that mutations occur randomly with respect to their value to an organism; selection then governs whether they are fixed in a population. This principle has… (More)

Transcriptional regulatory networks in bacteria: from input signals to output responses.

Aswin Seshasayee, Paul Bertone, Gillian M. Fraser, Nicholas M. Luscombe
Current opinion in microbiology
2006

Transcriptional regulatory systems play a central role in coordinating bacterial responses to diverse stimuli. These systems can be studied in progressive stages: from input signals to the final… (More)

Principles of transcriptional regulation and evolution of the metabolic system in E. coli.

Aswin Seshasayee, Gillian M. Fraser, M. Madan Babu, Nicholas M. Luscombe
Genome research
2009

Organisms must adapt to make optimal use of the metabolic system in response to environmental changes. In the long-term, this involves evolution of the genomic repertoire of enzymes; in the… (More)

Genome Sequencing Unveils a Novel Sea Enterotoxin-Carrying PVL Phage in Staphylococcus aureus ST772 from India

Sushma Prabhakara, Supriya Khedkar, +5 authors Gayathri Arakere
PloS one
2013

Staphylococcus aureus is a major human pathogen, first recognized as a leading cause of hospital-acquired infections. Community-associated S. aureus (CA-SA) pose a greater threat due to increase in… (More)

Context-dependent conservation of DNA methyltransferases in bacteria

Aswin Seshasayee, Parul Singh, Sandeep Krishna
Nucleic acids research
2012

DNA methytransferases (MTs) in bacteria are best understood in the context of restriction-modification (R-M) systems, which act as bacterial immune systems against incoming DNA including phages, but… (More)

Genome scale patterns of supercoiling in a bacterial chromosome

Avantika Lal, Amlanjyoti Dhar, Andrei N Trostel, Fedor Kouzine, Aswin Seshasayee, Sankar Adhya
Nature communications
2016

DNA in bacterial cells primarily exists in a negatively supercoiled state. The extent of supercoiling differs between regions of the chromosome, changes in response to external conditions and… (More)

Draft genome sequence of Staphylococcus aureus 118 (ST772), a major disease clone from India.

Sushma Prabhakara, Supriya Khedkar, +4 authors Aswin Seshasayee
Journal of bacteriology
2012

We report the draft genome sequence of an ST772 Staphylococcus aureus disease isolate carrying staphylococcal cassette chromosome mec (SCCmec) type V from a pyomyositis patient. Our de novo short… (More)

Genomic analysis reveals epistatic silencing of "expensive" genes in Escherichia coli K-12.

Rajalakshmi Srinivasan, Deepti Chandraprakash, +4 authors Aswin Seshasayee
Molecular bioSystems
2013

A barrier for horizontal gene transfer is high gene expression, which is metabolically expensive. Silencing of horizontally-acquired genes in the bacterium Escherichia coli is caused by the global… (More)

Genome and Transcriptome Adaptation Accompanying Emergence of the Definitive Type 2 Host-Restricted Salmonella enterica Serovar Typhimurium Pathovar

Robert A. Kingsley, Sally J. Kay, +17 authors Gordon Dougan
mBio
2013

Salmonella enterica serovar Typhimurium definitive type 2 (DT2) is host restricted to Columba livia (rock or feral pigeon) but is also closely related to S. Typhimurium isolates that circulate in… (More)

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