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Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids
  • U. Jin, Hyejin Park, +10 authors S. Safe
  • Chemistry, Medicine
  • Toxicological sciences : an official journal of…
  • 1 July 2018
Dietary flavonoids are used in treatment of multiple diseases, and their antiinflammatory effects in the intestine are due, in part, to interactions with gut microflora and possibly due to modulationExpand
Editor’s Highlight: Microbial-Derived 1,4-Dihydroxy-2-naphthoic Acid and Related Compounds as Aryl Hydrocarbon Receptor Agonists/Antagonists Structure–Activity Relationships and Receptor Modeling
  • Y. Cheng, U. Jin, +9 authors S. Safe
  • Chemistry, Medicine
  • Toxicological sciences : an official journal of…
  • 1 February 2017
1,4-Dihydroxy-2-naphthoic acid (1,4-DHNA) is a bacterial-derived metabolite that binds the aryl hydrocarbon receptor (AhR) and exhibits anti-inflammatory activity in the gut. The structure-dependentExpand
Isoflavones as Ah Receptor Agonists in Colon-Derived Cell Lines: Structure-Activity Relationships.
Many of the protective responses observed for flavonoids in the gastrointestinal track resemble aryl hydrocarbon receptor (AhR)-mediated effects. Therefore, we examined the structure-activityExpand
Uncovering the Binding and Specificity of β-Wrapins for Amyloid-β and α-Synuclein.
Amyloidogenic proteins amyloid-β peptide (Aβ) and α-synuclein (α-syn) self-assemble into fibrillar amyloid deposits, senile plaques and Lewy bodies, pathological features of Alzheimer's andExpand
A novel amyloid designable scaffold and potential inhibitor inspired by GAIIG of amyloid beta and the HIV‐1 V3 loop
The GAIIG sequence, common to the amyloid beta peptide (residues 29–33) and to the HIV‐1 gp120 (residues 24–28 in a typical V3 loop), self‐assembles into amyloid fibrils, as suggested by theory andExpand
Enhanced Fluorescence for Bioassembly by Environment-Switching Doping of Metal Ions.
The self-assembly of cyclodipeptides composed of natural aromatic amino acids into supramolecular structures of diverse morphologies with intrinsic emissions in the visible light region isExpand
Montmorillonites Can Tightly Bind Glyphosate and Paraquat Reducing Toxin Exposures and Toxicity
Among the numerous contaminants of soil, glyphosate and paraquat are two of the most widely used herbicides that are commonly detected in the environment. Soil and sediment contaminated withExpand
High-Efficiency Fluorescence through Bioinspired Supramolecular Self-Assembly
Peptide self-assembly has attracted extensive interest in the field of eco-friendly optoelectronics and bioimaging due to its inherent biocompatibility, intrinsic fluorescence, and flexibleExpand
Elucidating the multi-targeted anti-amyloid activity and enhanced islet amyloid polypeptide binding of β-wrapins
We use computational and experimental methods to investigate the molecular recognition of IAPP by β-wrapins. Expand
Virtual Screening of Chemical Compounds for Discovery of Complement C3 Ligands
The complement system is our first line of defense against foreign pathogens, but when it is not properly regulated, complement is implicated in the pathology of several autoimmune and inflammatoryExpand