Astrid Valette

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Stability of cell-to-cell interactions and integrity of junctional membrane proteins are essential for biological processes including cancer prevention. The present study shows that DDT, a non-genomic carcinogen used at a non-cytotoxic dose (1 microM), rapidly disrupted the cell-cell contacts and concomitantly induced the formation of cytoplasmic vacuoles(More)
Anchorage-dependent and -independent MCF-7 cell growth was dose-dependently inhibited by retinoic acid (RA) but was insensitive to TGF-beta (from 1 to 100 pM). Growth of MCF-7 monolayer cultures was inhibited (50%) when exposed to 10(-6) M RA. RA was unable to completely inhibit MCF-7 cell proliferation, as concentrations above 10(-6) M were rapidly(More)
Exposure of MCF-7 human mammary carcinoma cells to 12-0-tetradecanoylphorbol-13-acetate (TPA) results in changes in cell morphology and arrest of cell growth. The inhibition of cell proliferation and the increase in cell volume are concentration dependent; these effects are reversible upon removal of the tumor promoting agent. Electron micro scopic studies(More)
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