Sort by:

• Highly Influential Citations
• Citations
• Acceleration
• Velocity
• Recency

Learn More

The emerging therapeutic potential of histone methyltransferase and demethylase inhibitors.

• Astrid Spannhoff, Alexander-Thomas Hauser, Ralf Heinke, Wolfgang Sippl, Manfred Jung
• ChemMedChem
• 2009

Epigenetics is defined as heritable changes to the transcriptome that are independent of changes in the genome. The biochemical modifications that govern epigenetics are DNA methylation and… (More)

Target-based approach to inhibitors of histone arginine methyltransferases.

• Astrid Spannhoff, Ralf Heinke, +7 authors Manfred Jung
• Journal of medicinal chemistry
• 2007

Lysine and arginine methyltransferases participate in the post-translational modification of histones and regulate key cellular functions. So far only one arginine methyltransferase inhibitor… (More)

Cancer treatment of the future: inhibitors of histone methyltransferases.

• Astrid Spannhoff, Wolfgang Sippl, Manfred Jung
• The international journal of biochemistry & cell…
• 2009

Cancer in humans is the result of a multi-step process. This process often involves the activation of oncogenes and/or the inactivation of tumor suppressor genes. These two steps arise not only due… (More)

A novel arginine methyltransferase inhibitor with cellular activity.

• Astrid Spannhoff, Rospita Machmur, +7 authors Manfred Jung
• Bioorganic & medicinal chemistry letters
• 2007

Via virtual screening we identified a thioglycolic amide as an arginine methyltransferase (PRMT) inhibitor and tested it and related compounds against the fungal PRMT RmtA and human PRMT1. Compound… (More)

Virtual screening and biological characterization of novel histone arginine methyltransferase PRMT1 inhibitors.

• Ralf Heinke, Astrid Spannhoff, +4 authors Wolfgang Sippl
• ChemMedChem
• 2009

Lysine and arginine methyltransferases participate in the posttranslational modification of histones and regulate key cellular functions. Protein arginine methyltransferase 1 (PRMT1) has been… (More)

Design, synthesis and biological evaluation of carboxy analogues of arginine methyltransferase inhibitor 1 (AMI-1).

• Sabrina Castellano, Ciro Milite, +10 authors Gianluca Sbardella
• ChemMedChem
• 2010

Here we report the synthesis of a number of compounds structurally related to arginine methyltransferase inhibitor 1 (AMI-1). The structural alterations that we made included: 1) the substitution of… (More)

Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1.

• Sabrina Castellano, Astrid Spannhoff, +13 authors Gianluca Sbardella
• Journal of medicinal chemistry
• 2012

Arginine methylation is a common post-translational modification that is crucial in modulating gene expression at multiple critical levels. The arginine methyltransferases (PRMTs) are envisaged as… (More)

• ‹
• 1
• ›