Astrid Pañeda

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The objective of this research was to determine the quantitative trait loci (QTLs) controlling phenological traits (days to flowering, days to end of flowering, days to harvest as green pod, and days to maturity), seed size traits (seed length, seed height, seed width, and seed weight), and seed quality traits (water absorption, and coat proportion), in(More)
Allelism tests and molecular marker analyses were combined to characterize the genes that, proceeding from the germplasm lines ‘A493’ and ‘A321’, confer resistance to bean anthracnose in the new breeding lines ‘A1220’ and ‘A1231’, respectively, developed through backcross breeding, using the dry bean landrace ‘Andecha’ as the recurrent parent. Allelism(More)
Necrotic strains of bean common mosaic potyviruses are becoming increasingly problematic in bean growing areas of Africa and Europe. Pyramiding epistatic resistance genes provides the most effective long-term strategy for disease control against all known strains of the virus. Indirect selection using tightly linked markers should facilitate the breeding of(More)
A genetic map of common bean was constructed using 197 markers including 152 RAPDs, 32 RFLPs, 12 SCARs, and 1 morphological marker. The map was established by using a F2 population of 85 individuals from the cross between a line derived from the Spanish landrace Andecha (Andean origin) and the Mesoamerican genotype A252. The resulting map covers about(More)
UNLABELLED Obesity-induced insulin resistance is associated with both ectopic lipid deposition and chronic, low-grade adipose tissue inflammation. Despite their excess fat, obese individuals show lower fatty-acid oxidation (FAO) rates. This has raised the question of whether burning off the excess fat could improve the obese metabolic phenotype. Here we(More)
UNLABELLED We investigated whether gene transfer of insulin-like growth factor I (IGF-I) to the hepatic tissue was able to improve liver histology and function in established liver cirrhosis. Rats with liver cirrhosis induced by carbon tetrachloride (CCl(4)) given orally for 8 weeks were injected through the hepatic artery with saline or with Simian virus(More)
The liver is an attractive organ for gene therapy because of its important role in many inherited and acquired diseases. Recombinant adeno-associated viruses (rAAVs) have been shown to be good candidates for liver gene delivery, leading to long-term gene expression. We evaluated the influence of the route of administration on rAAV-mediated liver(More)
Chronic hepatitis B is a major cause of liver-related death worldwide. Interleukin-12 (IL-12) induction accompanies viral clearance in chronic hepatitis B virus infection. Here, we tested the therapeutic potential of IL-12 gene therapy in woodchucks chronically infected with woodchuck hepatitis virus (WHV), an infection that closely resembles chronic(More)
Resistance to races 19, 31, 38, 65, 73, 102, and 449, of the pathogenic fungus Colletotrichum lindemuthianum (anthracnose) was evaluated in F3 families derived from the cross between the anthracnose differential bean cultivars Mexico 222 (resistant to races 19, 31, and 38) and Widusa (resistant to races 38, 65, 73, 102, and 449). Molecular marker analyses(More)
Bulked segregant analysis (BSA) was used to identify molecular markers linked to determinate growth habit (fin gene) in a F2 population derived from the cross Andecha (FinFin) × BRB130 (finfin). Fourteen RAPD markers and one microsatellite (BMd45-AIA) were linked to the fin gene when tested on the entire population. The SCAR, SI19b, designed from the RAPD(More)