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UNLABELLED This paper discusses the arguments for and against radical tumor resection as a strategy for treatment of cerebral gliomas. METHOD Data from the Glioma Outcome Project were analyzed to determine whether survival could be related to extent of resection in 666 patients treated by biopsy or resection for malignant cerebral gliomas. FINDINGS(More)
AIMS To measure pimecrolimus blood concentrations and to evaluate tolerability and efficacy in children and infants treated topically for atopic dermatitis with pimecrolimus cream 1% for three weeks. METHODS Three open label, non-controlled, multiple topical dose studies were conducted in children aged 8-14 years (study A, ten patients), and in infants(More)
The purpose of this study was to determine the effects of knowledge of results, i.e., visual feedback from watching the torque curve on the Cybex II recorder, on knee extensor and flexor strength (peak torque in ft-lb), and fatigue (strength decrement) during reciprocal, isokinetic testing at speeds of 15O/sec (slow) and 300 degrees /sec (fast). Knowledge(More)
Objectives: To investigate the effect of enalapril, losartan, and surgical coronary revascularisation on endothelial function, and the role of the angiotensin converting enzyme (ACE) insertion (I)/deletion (D) polymorphism. Design: Randomised, controlled, blinded end point study. Setting: University tertiary referral cardiac centre. Patients and(More)
We evaluate the CyberKnife (Accuray Incorporated, Sunnyvale, CA, USA) for non-invasive delivery of accelerated partial breast irradiation (APBI) in early breast cancer patients. Between 6/2009 and 5/2011, nine patients were treated with CyberKnife APBI. Normal tissue constraints were imposed as outlined in the National Surgical Adjuvant Breast and Bowel(More)
(1997). Effect of noninvasive positive­pressure ventilation on survival in amyotrophic lateral sclerosis. (1995). A positron emission tomography study of frontal lobe function (verbal fluency) in amyotrophic lateral sclerosis. Linear estimates of rates of disease progression as predictors of survival in patients with ALS entering clinical trials.
A previously described difference in newborn blood phenylalanine concentrations between those living in urban and non-urban areas in the south west of England has been confirmed and shown to be independent of the type of feed. Several factors including the place of abode, type of feed, birthweight, and the accuracy of the test have been found to affect the(More)
of a preceding pregnancy had any effect on the outcome of the subsequent pregnancy. A first, second, or third pregnancy was taken as the index pregnancy and the outcome of the subsequent pregnancy examined. of unknown social class. The table shows the outcome of the pregnancy after the index pregnancy. There were 51 malformations after a normal pregnancy(More)