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Systematic identification of trans eQTLs as putative drivers of known disease associations
TLDR
Variants associated with cholesterol metabolism and type 1 diabetes showed similar phenomena, indicating that large-scale eQTL mapping provides insight into the downstream effects of many trait-associated variants. Expand
Biomechanical forces promote embryonic haematopoiesis
TLDR
A critical role for biomechanical forces in haematopoietic development is revealed in mouse embryos using mouse embryonic stem cells differentiated in vitro and that abrogation of nitric oxide, a mediator of shear-stress-induced signalling, compromises haem atopOietic potential in vivo and in vivo is revealed. Expand
The transcriptional landscape of age in human peripheral blood
TLDR
Differences between transcriptomic age and chronological age are associated with biological features linked to ageing, such as blood pressure, cholesterol levels, fasting glucose, and body mass index and the transcriptomic prediction model adds biological relevance and complements existing epigenetic prediction models. Expand
Validation of an atrial fibrillation risk algorithm in whites and African Americans.
TLDR
Risk of incident atrial fibrillation in community-dwelling whites and African Americans can be assessed reliably by routinely available and potentially modifiable clinical variables. Expand
Tubular Secretion in CKD.
TLDR
Estimates of proximal tubular secretion function correlate with glomerular filtration, but substantial variability in net secretion remains, and associations of net secretion with mortality and progression of CKD require confirmation. Expand
Blood pressure variability and the risk of all-cause mortality, incident myocardial infarction, and incident stroke in the cardiovascular health study.
TLDR
Long-term visit-to-visit SBP variability was independently associated with a higher risk of subsequent mortality and MI but not stroke, and more research is needed to determine the relationship of BP variability with cardiovascular risk and the clinical implications. Expand
Left Ventricular Mass, Brain Magnetic Resonance Imaging, and Cognitive Performance: Results From the Strong Heart Study
TLDR
The role of cardiovascular health in midlife as a target for the prevention of deleterious cognitive and functional outcomes in later life is emphasized, and associations between LVM and later imaging and cognition outcomes are modeled. Expand
Cranial Magnetic Resonance Imaging in Elderly American Indians: Design, Methods, and Implementation of the Cerebrovascular Disease and Its Consequences in American Indians Study
TLDR
The goal of the CDCAI Study is to characterize the burden, risk factors, and manifestations of vascular brain injury identified on cranial MRI. Expand
Variation in resting heart rate over 4 years and the risks of myocardial infarction and death among older adults
TLDR
Variation in RHR over a period of several years represents a potential predictor of long-term mortality among older persons free of cardiovascular disease. Expand
A culturally-tailored behavioral intervention trial for alcohol use disorders in three American Indian communities: Rationale, design, and methods.
TLDR
The HONOR Study is designed to determine whether a culturally-tailored contingency management intervention is an effective intervention for AI/AN adults who suffer from alcohol use disorders, and the primary study outcome is urinary ethyl glucuronide-confirmed alcohol abstinence. Expand
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