Astrid Karstens

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Syphilitic heart disease is a misnomer, for the basic lesion in syphilitic heart disease is an aortitis. This, in turn, consists of a perivascular lymphocytic infiltration of the vasa-vasorum in response to the invasion of the spirochete. Depending upon the extent and the degree of this infection within the aorta, we may have, complicating the basic lesion(More)
To evaluate the predicted mortality rate of oncologic patients in the PICU using the PRISM score and factors that might influence short-term outcomes. Retrospective study.Setting: Pedriatic ICU in a university hospital The medical charts of all oncologic patients admitted to the PICU during the period from January 1983 to December 1992 were reviewed. Over a(More)
Diseases in childhood have an impact on growth. The influence of Langerhans cell histiocytosis (LCH) on growth has never been studied well. Recently a patient with LCH was treated with human growth hormone (GH) because of severe GH deficiency due to LCH involvement of both the hypothalamus and pituitary. This led us to review our charts from 1971 onward for(More)
PURPOSE The aim of the study was to analyze patients' busulfan (BU) exposure after oral administration of extemporeanously prepared BU capsules prior to blood stem cell transplantation. METHODS Patients were treated with 1 mg/kg body weight BU administered orally every 6h on each of 4 consecutive days prior to blood stem cell transplantation. Each BU dose(More)
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