A role for mitochondrial glycerol-3-phosphate dehydrogenase (mGPD) in thermogenesis was investigated in transgenic mice lacking the mGPD gene (mGPD-/-). Reared and studied at 22 C, these mice have a small, but significant, reduction (7-10%) in energy expenditure, as evidenced by oxygen consumption (QO2) and food intake, and show signs of increased brown… (More)
To define the role of mitochondrial glycerol-3-phosphate dehydrogenase (mGPD; EC 220.127.116.11) in energy balance and intermediary metabolism, we studied transgenic mice not expressing mGPD (mGPD-/-). These mice had approximately 14% lower blood glucose; approximately 50% higher serum glycerol; approximately 80% higher serum triglycerides; and at… (More)
BACKGROUND There is rapid increase in the incidence of Diabetes Mellitus (DM) in the Kingdom of Saudi Arabia (KSA), as in other countries. An optimal care of diabetic patients depends on the health care providers as well as the type of health care setting. Due to the severity of chronic complications in Type 2 diabetic patients, it is essential to assess… (More)
We report a case of overt hypothyroidism that was associated with a preeclampsia-like syndrome and fetal death in a 37-year-old woman (gravidity, 7; parity, 6). Rapid and robust correction of hypothyroidism is recommended in this situation.