Asli Bauer

Christof Geldmacher4
Michael Hoelscher4
Petra Clowes3
Leonard Maboko3
Mkunde Chachage3
4Christof Geldmacher
4Michael Hoelscher
3Petra Clowes
3Leonard Maboko
3Mkunde Chachage
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BACKGROUND It has been hypothesized that helminth infections increase HIV susceptibility by enhancing systemic immune activation and hence contribute to elevated HIV-1 transmission in sub-Saharan Africa. OBJECTIVE To study systemic immune activation and HIV-1 co-receptor expression in relation to different helminth infections and in response to helminth(More)
Protein production in cells is dependent on various factors including the underlying nucleotide sequence. Gene optimization is dedicated to improve the expression properties of transgenes by codon adaptation to the individual host, increasing RNA production, stability and nuclear export. However, most gene optimization strategies depend on codon usage(More)
BACKGROUND The presence of IgG and IgM against Tat, an HIV protein important for viral replication and immune dysfunction, is associated with slow disease progression in clade B HIV-infected individuals. However, although Tat activities strictly depend on the viral clade, our knowledge about the importance of anti-Tat antibodies in non-clade B HIV infection(More)
  • Damien Portevin, Félicien Moukambi, Maxmillian Mpina, Asli Bauer, Frederick Haraka, Mkunde Chachage +9 others
  • 2015
It is well accepted that aging and HIV infection are associated with quantitative and functional changes of CMV-specific T cell responses. We studied here the expression of Mip-1β and the T cell maturation marker CD27 within CMVpp65-specific CD4(+) and CD8(+) T cells in relation to age, HIV and active Tuberculosis (TB) co-infection in a cohort of Tanzanian(More)
  • Patricia. J. Munseri, Arne Kroidl, Charlotta Nilsson, Agricola Joachim, Christof Geldmacher, Philipp Mann +23 others
  • 2015
BACKGROUND Intradermal priming with HIV-1 DNA plasmids followed by HIV-1MVA boosting induces strong and broad cellular and humoral immune responses. In our previous HIVIS-03 trial, we used 5 injections with 2 pools of HIV-DNA at separate sites for each priming immunization. The present study explores whether HIV-DNA priming can be simplified by reducing the(More)
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