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Identification of new inhibitors for human hematopoietic prostaglandin D2 synthase among FDA-approved drugs and other compounds.
TLDR
Kinetic inhibition analysis showed that erythrosine sodium is a nonlinear competitive inhibitor of HPGDS, while suramin, tannic acid and sanguinarine sulfate are linear competitive inhibitors. Expand
Glutathione transferases immobilized on nanoporous alumina: flow system kinetics, screening, and stability.
TLDR
The previously uncharacterized Drosophila melanogaster Epsilon-class glutathione transferases E6 and E7 were immobilized on nanoporous alumina, and the amino groups were activated with carbonyldiimidazole to allow coupling of the enzymes via ε-amino groups. Expand
Overexpression of Glutathione Transferase E7 in Drosophila Differentially Impacts Toxicity of Organic Isothiocyanates in Males and Females
TLDR
The GSTE7 transgene elicits responses to exposure to ITC allelochemicals which differentially affect life-span and fecundity of male and female flies. Expand
β-actin regulates a heterochromatin landscape essential for optimal induction of neuronal programs during direct reprograming
TLDR
It is shown that heterochromatin alteration in β-actin null MEFs impedes the induction of neuronal gene programs during direct reprograming, in line with the notion that H3K9Me3-based heterochromaatin forms a major epigenetic barrier during cell fate change. Expand
Expression of a Drosophila glutathione transferase in Arabidopsis confers the ability to detoxify the environmental pollutant, and explosive, 2,4,6-trinitrotoluene.
TLDR
Described a Drosophila melanogaster glutathione transferase (DmGSTE6) which has activity towards TNT, producing a compound with potential for further biodegradation and contributing towards development of phytoremediation strategies to clean up TNT from polluted military sites. Expand
Drosophila GSTs display outstanding catalytic efficiencies with the environmental pollutants 2,4,6-trinitrotoluene and 2,4-dinitrotoluene
TLDR
It is demonstrated that different human glutathione transferases (GSTs) and GSTs from the fruit fly Drosophila melanogaster are catalysts of the biotransformation of TNT and DNT. Expand
Comparison of epsilon- and delta-class glutathione S-transferases: the crystal structures of the glutathione S-transferases DmGSTE6 and DmGSTE7 from Drosophila melanogaster.
TLDR
Drosophila melanogaster GSTs (DmGSTs) are likely to contribute to detoxication or antioxidative stress during development, but they have not been fully characterized and the structures are remarkably similar; the structures do not reveal obvious sources of the minor functional differences that have been observed. Expand
Potent inhibitors of equine steroid isomerase EcaGST A3-3
TLDR
The most potent inhibitors, anthralin, sennoside A, tannic acid, and ethacrynic acid, were characterized by IC50 values in the submicromolar range when assayed with the natural substrate Δ5-androstene-3,17-dione. Expand
Inhibition characteristics of equine steroid isomerase EcaGST A3-3
Equine glutathione transferase A3-3 (EcaGST A3-3) belongs to the superfamily of detoxifying enzymes found in all organisms. However it is also the most efficient steroid double-bond isomerase knownExpand
Studies on Human and Drosophila melanogaster Glutathione Transferases of Biomedical and Biotechnological Interest
Glutathione transferases (GSTs, EC.2.5.1.18) are multifunctional enzymes that are universally distributed in all cellular life forms. They play important roles in metabolism and detoxication of endExpand