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- Publications
- Influence
Design, synthesis and molecular modeling studies on novel moxifloxacin derivatives as potential antibacterial and antituberculosis agents.
- Aslı Türe, Necla Kulabaş, +6 authors I. Küçükgüzel
- Chemistry, Medicine
- Bioorganic chemistry
- 1 July 2019
Twenty-one novel alkyl/acyl/sulfonyl substituted fluoroquinolone derivatives were designed, synthesized and evaluated for their anti-tuberculosis and antibacterial activity. The targeted compounds… Expand
Synthesis, computational molecular docking analysis and effectiveness on tyrosinase inhibition of kojic acid derivatives.
- G. Karakaya, Aslı Türe, A. Ercan, Selin Öncül, M. Aytemir
- Chemistry, Medicine
- Bioorganic chemistry
- 1 July 2019
Tyrosinase inhibitors have become increasingly important as whitening agents and for the treatment of pigmentary disorders. In this study, the synthesis of kojic acid derivatives having… Expand
Molecular modeling and assessment of cytotoxic and apoptotic potentials of imatinib analogues featuring (thio)urea motifs in human leukemia and lymphoma cells
- O. Ozakpinar, Aslı Türe, I. Küçükgüzel
- Chemistry
- 16 November 2020
Imatinib is a well-known anticancer drug. In this study, cytotoxic properties of thirty-two imatinib analogues featuring (thio)urea motifs have been evaluated against chronic myeloid leukemia (K562),… Expand
Design, synthesis, and anticancer activity of novel 4-thiazolidinone-phenylaminopyrimidine hybrids
- Aslı Türe, M. Ergül, M. Ergül, A. Altun, I. Küçükgüzel
- Chemistry, Medicine
- Molecular Diversity
- 23 April 2020
Abstract 4-Thiazolidinones and phenylaminopyrimidines are known as anticancer agents. Imatinib is the pioneer phenylaminopyrimidine derivative kinase inhibitor, which is used for the treatment of… Expand
Novel 2,6-disubstituted pyridine hydrazones: Synthesis, anticancer activity, docking studies and effects on caspase-3-mediated apoptosis
- Sevil Şenkardeş, Aslı Türe, +6 authors Ş. G. Küçükgüzel
- Chemistry
- 5 January 2021
Abstract Novel pyridine-based dihydrazones (3a-l) were synthesized by the condensation of appropriate aldehydes and pyridine-2,6-dicarbohydrazide (2) which was obtained by the treatment of dimethyl… Expand