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BACKGROUND The aim of the present prospective observational study was to assess the tolerability and antihyperglycemic efficacy of metformin extended-release (MXR) in the routine treatment of patients with type 2 diabetes mellitus (T2DM) from six Asian countries. METHODS Data from 3556 patients treated with once-daily MXR for 12 weeks, or until(More)
BACKGROUND Diabetes is associated with mishandling of thiamine in the kidney and development of diabetic nephropathy. The aim of this study is to assess the disturbance of thiamine and other B-vitamin status of patients with type 2 diabetes in Indonesia. METHODS One hundred and fifteen patients with type 2 diabetes with and without microalbuminuria or(More)
A comparative study, using a crossover design, was carried out on 260-well controlled diabetic out- patients to investigate the metabolic effects of the A (50% cal carbohydrate, 30% cal fat, and 20% cal protein) and the B-diets (Study I), since the adherence of diabetic patients to the A-diet is very poor, and uncontrolled diabetes ensues. In Indonesian(More)
Peroxisome Proliferator-Activate Receptors (PPARs) are transcription factors belonging to the nuclear receptor superfamily. The three PPARs (alpha, beta/delta, and gamma) are distributed differently in the different organs. PPARalpha is most common in the liver, but also found in kidney, gut, skeletal muscle and adipose tissue, while PPARbeta/delta, is(More)
OBJECTIVES Primary aim: does general practitioner (GP) education on type 2 diabetes treatment improve HbA1c? Secondary aim: cardiovascular risk factors, hypoglycaemia, treatment intensification, health service utilisation, treatment barriers. METHODS 99 Asia-Pacific GPs were cluster-randomised to be educated on regional diabetes management guidelines(More)
Vasa vasorum anti-angiogenesis through H 2 O 2 , HiF-1α, nF-κB, and inOs inhibition by mangosteen pericarp ethanolic extract (Garcinia mangostana linn) in hypercholesterol-diet-given Rattus norvegicus Wistar strain Titin andri Wihastuti
We assessed peripheral and autonomic nerve function in 27 diabetics. Ten had malnutrition-related diabetes mellitus (MRDM), eight insulin-dependent diabetes mellitus (IDDM), and nine non-insulin-dependent diabetes mellitus (NIDDM). The frequency of peripheral neuropathy was 70, 78 and 13% in MRDM, NIDDM and IDDM respectively. Furthermore, the frequency of(More)
BACKGROUND Oxidative stress in atherosclerosis produces H2O2 and triggers the activation of nuclear factor kappa beta (NF-κB) and increase of inducible nitric oxide synthase (iNOS). The formation of vasa vasorum occurs in atherosclerosis. Vasa vasorum angiogenesis is mediated by VEGFR-1 and upregulated by hypoxia-inducible factor-1α (HIF-1α). The newly(More)