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The pathways by which mammalian Ras proteins induce cortical actin rearrangement and cause cellular transformation are investigated using partial loss of function mutants of Ras and activated and inhibitory forms of various postulated target enzymes for Ras. Efficient transformation by Ras requires activation of other direct effectors in addition to the MAP(More)
Upon detachment from the extracellular matrix, epithelial cells enter into programmed cell death, a phenomenon known as anoikis, ensuring that they are unable to survive in an inappropriate location. Activated ras oncogenes protect cells from this form of apoptosis. The nature of the survival signals activated by integrin engagement and usurped by oncogenic(More)
As a dendritic cell (DC) matures, it becomes more potent as an antigen-presenting cell. This functional change is accompanied by a change in DC immunophenotype. The signal transduction events underlying this process are poorly characterized. In this study, we have investigated the signal transduction pathways involved in the lipopolysaccharide (LPS)-induced(More)
Detachment of epithelial cells from the ex-tracellular matrix leads to induction of programmed cell death, a process that has been termed " anoikis. " It has been reported recently that detachment of MDCK cells from matrix results in activation of Jun–NH 2-terminal kinases (JNKs) and speculated that these stress activated protein kinases play a causal role(More)
In recent years, statistically motivated approaches for the registration and tracking of non-rigid objects, such as the Active Appearance Model (AAM), have become very popular. A major drawback of these approaches is that they require manual annotation of all training images which can be tedious and error prone. In this paper, a MPEG-4 based approach for(More)
The prevention of apoptosis is a key function of growth factors in the regulation of erythropoiesis. This study examined the role of the constitutively active serine/threonine kinase glycogen synthase kinase-3 (GSK3), a target of the phosphoinositide-3-kinase (PI3K)/Akt pathway, in the regulation of apoptosis in primary human erythroid progenitors. GSK3(More)
Detachment of epithelial cells from the extracellular matrix leads to induction of programmed cell death, a process that has been termed "anoikis." It has been reported recently that detachment of MDCK cells from matrix results in activation of Jun-NH2-terminal kinases (JNKs) and speculated that these stress activated protein kinases play a causal role in(More)
NOTCH1 is frequently mutated in T-cell acute lymphoblastic leukaemia (T-ALL), and can stimulate T-ALL cell survival and proliferation. Here we explore the hypothesis that Notch1 also alters T-ALL cell migration. Rho GTPases are well known to regulate cell adhesion and migration. We have analysed the expression levels of Rho GTPases in primary T-ALL samples(More)
The sparse representation technique has provided a new way of looking at object recognition. As we demonstrate in this paper, however, the mean-squared error (MSE) measure, which is at the heart of this technique, is not a very robust measure when it comes to comparing facial images, which differ significantly in lu-minance values, as it only performs(More)