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The pathways by which mammalian Ras proteins induce cortical actin rearrangement and cause cellular transformation are investigated using partial loss of function mutants of Ras and activated and inhibitory forms of various postulated target enzymes for Ras. Efficient transformation by Ras requires activation of other direct effectors in addition to the MAP(More)
In recent years, statistically motivated approaches for the registration and tracking of non-rigid objects, such as the Active Appearance Model (AAM), have become very popular. A major drawback of these approaches is that they require manual annotation of all training images which can be tedious and error prone. In this paper, a MPEG-4 based approach for(More)
Detachment of epithelial cells from the extracellular matrix leads to induction of programmed cell death, a process that has been termed "anoikis." It has been reported recently that detachment of MDCK cells from matrix results in activation of Jun-NH2-terminal kinases (JNKs) and speculated that these stress activated protein kinases play a causal role in(More)
NOTCH1 is frequently mutated in T-cell acute lymphoblastic leukaemia (T-ALL), and can stimulate T-ALL cell survival and proliferation. Here we explore the hypothesis that Notch1 also alters T-ALL cell migration. Rho GTPases are well known to regulate cell adhesion and migration. We have analysed the expression levels of Rho GTPases in primary T-ALL samples(More)
The sparse representation technique has provided a new way of looking at object recognition. As we demonstrate in this paper, however, the mean-squared error (MSE) measure, which is at the heart of this technique, is not a very robust measure when it comes to comparing facial images, which differ significantly in lu-minance values, as it only performs(More)
Protein kinase C iota (PKCι), a serine/threonine kinase required for cell polarity, proliferation and migration, is commonly up- or downregulated in cancer. PKCι is a human oncogene but whether this is related to its role in cell polarity and what repertoire of oncogenes acts in concert with PKCι is not known. We developed a panel of candidate oncogene(More)
Wilms' Tumour 1 (WT1) is a zinc finger transcription factor that is over-expressed in acute myeloid leukaemia (AML). Its restricted expression in normal tissues makes it a promising target for novel immunotherapies aiming to accentuate the cytotoxic T lymphocyte (CTL) response against AML. Here we report a phase I/II clinical trial of subcutaneous peptide(More)
Multiple myeloma (MM) is a clinically and genetically heterogenous cancer where tumour cells have dysregulated expression of a D-type cyclin, often in association with a recurrent IgH translocation. Patients whose tumour cells express cyclin D2, with the translocation t(4;14) or t(14;16), generally have more proliferative disease and inferior outcomes. The(More)
A neuro-physiologically inspired model is presented for the contrast enhancement of images. The contrast of an image is calculated using simulated on-and off-centre receptive fields whereby obtaining the corresponding two contrast maps. We propose an adaptive asymmetric gain control function that is applied to the two contrast maps which are then used to(More)
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