Asif Rizwan

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Purpose: We compared the metabolic profiles and the association between LDH-A expression and lactate production in two isogenic murine breast cancer cell lines and tumors (67NR and 4T1). These cell lines were derived from a single mammary tumor and have different growth and metabolic phenotypes. Experimental Design: LDH-A expression, lactate concentration,(More)
In vivo knowledge of the spatial distribution of viable, necrotic, and hypoxic areas can provide prognostic information about the risk of developing metastases and regional radiation sensitivity and may be used potentially for localized dose escalation in radiation treatment. In this study, multimodality in vivo magnetic resonance imaging (MRI) and positron(More)
PURPOSE To investigate the relationship between lactate dehydrogenase A (LDH-A) expression, lactate concentration, cell metabolism, and metastases in murine 4T1 breast tumors. EXPERIMENTAL DESIGN Inhibition of LDH-A expression and protein levels were achieved in a metastatic breast cancer cell line (4T1) using short hairpin RNA (shRNA) technology. The(More)
The authors regret that there are typos in the section " Dynamic Contrast-Enhanced MRI. " For the T 1-weighted DCE-MRI, a fast low-angle shot (FLASH) sequence was used with a 41.77 ms TR and 5 slices (not 33 ms TR and 4 slices as stated originally), resulting in a temporal resolution of 5.347 seconds. These were pure typographical errors and do not affect(More)
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