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Human Immunodeficiency Virus-1 Impairs IFN-Alpha Production Induced by TLR-7 Agonist in Plasmacytoid Dendritic Cells.
Plasmacytoid dendritic cells (pDCs) play an important role in innate immune response against viruses, mainly through interferon-α (IFN-α) secretion. Impaired IFN-α secretion has been observed in… Expand
Molecular Modeling, Synthesis and Biological Evaluation of N‐Heteroaryl Compounds as Reverse Transcriptase Inhibitors Against HIV‐1
- Anuradha Singh, Dipti Yadav, M. Yadav, Ashwini Dhamanage, S. Kulkarni, R. K. Singh
- Biology, Medicine
- Chemical biology & drug design
- 1 March 2015
Different N‐heteroaryl compounds bearing pyrimidine and benzimidazole moieties have been designed in silico using Discovery studio 2.5 software, synthesized and evaluated for their inhibitory… Expand
Incomplete functional T-cell reconstitution in immunological non-responders at one year after initiation of antiretroviral therapy possibly predisposes them to infectious diseases.
- A. Shete, Sampada Dhayarkar, +6 authors R. Gangakhedkar
- International journal of infectious diseases…
- 1 April 2019
BACKGROUND Immunological non-responders (INR) represent a unique category of HIV-infected patients on antiretroviral therapy. These patients have suppressed viremia but a suboptimal increase in CD4… Expand
HIV-1-Mediated Suppression of IFN-α Production Is Associated with Inhibition of IRF-7 Translocation and PI3K/akt Pathway in Plasmacytoid Dendritic Cells.
- Ashwini Dhamanage, M. Thakar, R. Paranjape
- Biology, Medicine
- AIDS research and human retroviruses
- 11 January 2019
Interferon-α (IFN-α) plays a vital role in combating viral infections especially in the early control after infection. However, the HIV infection has shown substantial level of suppression of IFN-α… Expand
Possible role of plasma Galectin-9 levels as a surrogate marker of viremia in HIV infected patients on antiretroviral therapy in resource-limited settings
- A. Shete, Sampada Dhayarkar, +8 authors R. Gangakhedkar
- AIDS Research and Therapy
- 16 July 2020
Background Early detection of viremia in HIV infected patients on anti-retroviral therapy (ART) is important to prevent disease progression as well as accumulation of drug resistance mutations. This… Expand
Design, synthesis and biological evaluation on N- heteroaryl compounds as probable NNRTIs against laboratory adapted strains and the primary isolates of HIV-1
Methods Compounds designed on the basis of extensive computational studies, were finally synthesized through facile synthetic route and characterized using various chromatographic and spectral… Expand
IN VITRO ANTI-HIV ACTIVITY STUDIES ON ENICOSTEMA LITTORALE (LAM), RAYNAL.WHOLE PLANTS
S Enicostema axillare (Lam.).Raynal, syn. Enicostemma littorale Blume (Family) Gentinaceae is a perennial herb found throughout the greater part of India.Locally it is known as chota chirayita and… Expand