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—There is an abundance of business process modeling techniques that capture and address different aspects of a business process. A limited number of these process models allow further quantitative analysis, and only a few enable structured process improvement. This paper reviews and classifies the main techniques for business process modeling with regard to(More)
A business incurs much higher charges when attempting to win new customers than to retain existing ones. As a result, much research has been invested into new ways of identifying those customers who have a high risk of churning. However customer retention efforts have also been costing organisations large amounts of resource. In response to these issues,(More)
Traditional methods often employed to solve complex real world problems tend to inhibit elaborate exploration of the search space. They can be expensive and often results in sub-optimal solutions. Evolutionary computation (EC) is generating considerable interest for solving real world engineering problems. They are proving robust in delivering global(More)
—The difficulties faced by existing Multi-objective Evolutionary Algorithms (MOEAs) in handling many-objective problems relate to the inefficiency of selection operators, high computational cost and difficulty in visualization of objective space. While many approaches aim to counter these difficulties by increasing the fidelity of the standard selection(More)
Dying-back degeneration of motor neuron axons represents an established feature of familial amyotrophic lateral sclerosis (FALS) associated with superoxide dismutase 1 (SOD1) mutations, but axon-autonomous effects of pathogenic SOD1 remained undefined. Characteristics of motor neurons affected in FALS include abnormal kinase activation, aberrant(More)
'Gain' of supernumerary copies of the 8q24.21 chromosomal region has been shown to be common in many human cancers and is associated with poor prognosis. The well-characterized myelocytomatosis (MYC) oncogene resides in the 8q24.21 region and is consistently co-gained with an adjacent 'gene desert' of approximately 2 megabases that contains the long(More)
The biological basis of preferential motor neuron degeneration in amyotrophic lateral sclerosis (ALS) remains incompletely understood, and effective therapies to prevent the lethal consequences of this disorder are not yet available. Since 1993, more than 100 mutant variants of the antioxidant enzyme Cu/Zn superoxide dismutase (SOD1) have been identified in(More)