Ashootosh V Ambade

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This review highlights the developments in dendrimer-based micelles for drug delivery. Dendrimers, the perfectly branched monodisperse macromolecules, have certain structural advantages that make them attractive candidates as drug carriers for controlled release or targeted delivery. As polymeric micelle-based approaches precede the work in dendrimers,(More)
Block copolymers are key building blocks for a variety of applications ranging from electronic devices to drug delivery. The material properties of block copolymers can be tuned and potentially improved by introducing noncovalent interactions in place of covalent linkages between polymeric blocks resulting in the formation of supramolecular block(More)
Glycopolypeptides (GPs) were synthesized by ring-opening polymerization of glycosylated N-carboxyanhydride monomer and attached to hydrophobic dendrons at one chain end by "click" reaction to obtain amphiphilic anisotropic macromolecules. We show that by varying polypeptide chain length and dendron generation, an organogel was obtained in dimethylsulfoxide,(More)
Just add it! Ruthenium initiators functionalized with hydrogen-bonding sites were utilized in ring-opening metathesis polymerization to prepare heterotelechelic polymers with hydrogen-bonding and metal-coordination units in a single step. Supramolecular ABC triblock copolymers were then self-assembled in one pot by simply adding complementary telechelic(More)
Facially amphiphilic dendrimers have been shown to provide significant difference in surface behavior due to subtle changes in structure. The monodendrons are capable of providing hydrophobic surfaces, while the didendrons provide superhydrophobic surfaces. This provides an example of how a molecular level change could result in significant changes in(More)
A bimetallic ruthenium olefin metathesis initiator was synthesized and used to polymerize functionalized norbornenes, affording polymers that are living at both polymer chain-ends. Using this bis-ruthenium initiator strategy and combining it with functional chain-terminators, highly-efficient syntheses of either SCS-Pd(II) pincer- or pyridine-functionalized(More)
A heterotelechelic poly(norbornene imide) containing two terminal and orthogonal hydrogen-bonding receptors, N,N'-bis[6-(alkanoylamino)pyridin-2-yl] isophthalamide (often referred to as the Hamilton receptor or Wedge) and 2,7-diamido-1,8-naphthyridine (DAN), at the opposite ends of the polymer was synthesized via ring-opening metathesis polymerization(More)
Synthesis and micellar behavior of biaryl-based benzyl ether dendritic molecules prepared from a new biaryl building block are described. The key objective of the study is to tune the size of individual dendritic molecules and investigate its effect on aggregation behavior of the resulting micelle-like assemblies. We show that the functional group placement(More)
Spectral signatures in the terahertz (THz) frequency region are mainly due to bulk vibrations of the molecules. These resonances are highly sensitive to the relative position of atoms in a molecule as well as the crystal packing arrangement. To understand the variation of THz resonances, THz spectra (2-10 THz) of three structural isomers: 2-, 3-, and(More)
The role of molecular interactions in governing lipid mesophase organization is of fundamental interest and has technological implications. Herein, we describe an unusual pathway for monoolein/water reorganization from a bicontinuous mesophase to a discontinuous reverse micellar assembly, directed by the inclusion of polar macromolecules. This pathway is(More)