Ashok V. Bhosale

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Purpose: This investigation was carried out to determine if a solid dispersion of furosemide in sodium starch glycolate (SSG) would enhance the dissolution properties of the drug. Methods: Solid dispersion of furosemide in SSG was prepared in ratios of 1:1 and 1 (furosemide):2 (SSG) by kneading method. In each case, the solid dispersion was characterized by(More)
Purpose: The present study was undertaken to investigate diuretic effect of aqueous and methanol extracts of the dried seeds of Lepidium sativum in normal rats. Method: Aqueous and methanol extracts of L. sativum seeds were administered to experimental rats orally at doses of 50 and 100 mg/kg p.o. Hydrochlorothiazide (10 mg/kg) was used as positive control(More)
Acid-peptic ulcers and diseases have been increasingly on rise in today's era of globalization, which is characterized by hurry, worry, and curry. This review summarizes various disorders associated with increased gastric acid secretion and various therapeutic strategies to control them. The emphasis has been laid, in particular, on the role of proton pump(More)
The buccal mucoadhesive tablets of nifedipine were fabricated with objective of avoiding first pass metabolism and prolonging duration of action. The mucoadhesive polymers used in formulations were carbopol (cp934), hydroxyl propyl methyl cellulose (HPMC K4M), carboxy methyl cellulose (CMC), and tamarind seed polysaccharide (TSP) .These formulations were(More)
Intranasal route of administration shows potential for delivery of drugs to brain. The nose-to-brain drug delivery of drugs is advantageous as it requires low dose of drug, avoids first pass effect. Also it is fast in action and suitable for the drugs that degrade in gastrointestinal tract. Nose-to-brain delivery also avoids blood brain barrier which is(More)
Purpose: To develop a simple, rapid and selective method for the extractive spectrophotometric determination of omeprazole using acidic dyes. Methods: Extractive spectrophotometric determination of omeprazole was developed using acidic dyes bromophenol blue and orange G as ion-pairing agents in aqueous medium (pH 7.0 and 6.0, respectively). The ion pair(More)
Relatively insoluble candidate drug like carbamazepine (CBZ) often exhibit incomplete or erratic absorption; and hence wide consideration is given to improve aqueous solubility of such compound. Dissolution of carbamazepine was improved in the present work using novel swellable hydrogel (mucilage) isolated from the seeds of Ocimum basilicum (Gel).Solid(More)
The limitations of currently available oral antidiabetic agents either in terms of efficacy/safety coupled with the emergence of the disease into global epidemic have encouraged alternative therapy that can manage diabetes more efficiently and safely. Herbal medications are the most commonly domestic medicines accepted as alternative therapy for blood sugar(More)
Objective: Benzothiazole is known to be pharmacologically active moiety with anti-inflammatory potential. Present work describes synthesis of some potentially active derivatives of 2-aminobenzothiazoles incorporated with isoindolinediones. The design of target compounds was based on chemical hybridization of two pharmacophores, benzothiazole and(More)
A rapid and sensitive high performance liquid chromatography method for determination of paracetamol and promethazine hydrochloride has been developed. The chromatography system used a reversed phase C18 column (HiQ Sil C18, 5μ, 250 mm x 4.6 mm). The sample was analyzed using Methanol: Water: Try ethyl amine, in the ratio of 90:10:0.1 v/v as a mobile phase(More)