Ashok Sahai

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The present study was conducted to investigate the possible interaction between low doses of nicotine and pentylenetetrazole (PTZ) in vivo and also to evaluate the influence of nicotine on the antiseizure efficacy of topiramate and sodium valproate in the PTZ-induced seizure model in mice. Graded dose-response study with nicotine showed the CD50 value for(More)
The present study aimed at establishing two models of experimental seizures by combination treatment with subconvulsive doses of PTZ and kainic acid in adult male mice and evaluating the modulatory role of cerebroselective dihydropyridine calcium channel blocker, nimodipine. The CD50 +/- SEM value for PTZ was found to be 20.00 +/- 0.92 mg/kg, ip in kainic(More)
INTRODUCTION Tobacco smoking is a widespread phenomenon, and nicotine is the addictive component of tobacco. Nicotine acts through nicotinic cholinergic receptors and has been associated with different types of psychophysical disorders in human beings. The present study had explored the proconvulsive action of nicotine and its effect on the antiseizure(More)
The nonlinear convectively coupled character of the summer monsoon intraseasonal oscillation (ISO) that manifests in its event-to-event variations is a major hurdle for skillful extended-range prediction of the active/break episodes. The convectively coupled character of the monsoon ISO implies that a particular nonlinear phase of the precipitation ISO is(More)
The distribution of neuronal nitric oxide synthase (nNOS) containing neurons and fibers in subnuclei of the nucleus tractus solitarii (NTS) in the squirrel monkey, Saimuri sciureus, was investigated by nNOS immunohistochemistry and nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase histochemistry. Generally, the staining pattern of nNOS and(More)
BACKGROUND Nicotine is heavily used addictive drug that has unpleasant side- effects, e.g. dizziness, nausea, emphysema. PURPOSE The current study was designed to find the possible relationship of nicotine mediated microcystic oedema in white matter of cerebellum to postural imbalance. METHODS Nicotine was administered for 8 weeks orally via cannula,(More)
Several observations now support the view that the sympathetic system actively participates in the development of cardiac hypertrophy. Since norepinephrine (NE)-containing neurons involved in cardiovascular regulation in the brain are known to coexist with neuropeptide Y (NPY), it is possible that a functional interaction between NPY and NE exists(More)
Weather forecasting has been an area of considerable interest among researchers since long. In particular, precipitation has been found to be interesting because of its chaotic nature and also because of the direct impact it has on the society. Even after the invention of complex Coupled Numerical Weather Prediction Models, the errors in prediction have(More)