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Prospective natural history study of central nervous system hemangioblastomas in von Hippel-Lindau disease.
OBJECT The tumors most frequently associated with von Hippel-Lindau (VHL) disease are hemangioblastomas. While they are associated with significant neurological impairment and mortality, theirExpand
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Long-term natural history of neurofibromatosis Type 2-associated intracranial tumors.
OBJECT Neurofibromatosis Type 2 (NF2) is a heritable tumor predisposition syndrome that leads to the development of multiple intracranial tumors, including meningiomas and schwannomas. Because theExpand
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Functional outcome after resection of spinal cord hemangioblastomas associated with von Hippel-Lindau disease.
OBJECT Spinal cord hemangioblastomas are a common protean manifestation of von Hippel-Lindau (VHL) disease and can be associated with significant morbidity. To better define expected outcome andExpand
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Surgery Insight: the role of surgery in the management of low-grade gliomas
The benefits of surgery for the management of low-grade gliomas have been difficult to determine from the literature. This difficulty might be explained by the inconsistency of the published data,Expand
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Image-guided convection-enhanced delivery of muscimol to the primate brain.
OBJECT Muscimol is a potent gamma-aminobutyric acid-A receptor agonist that temporarily and selectively suppresses neurons. Targeted muscimol suppression of neuronal structures could provide insightExpand
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Single-center experience with pediatric Cushing's disease.
OBJECT Despite ongoing advances in surgical and radiotherapeutic techniques, pediatric Cushing's disease remains a diagnostic and therapeutic challenge. The authors report on the results of aExpand
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Advances in brain tumor surgery.
Advances in the fields of molecular and translational research, oncology, and surgery have emboldened the medical community to believe that intrinsic brain tumors may be treatable. IntraoperativeExpand
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Neurofibromatosis type 2
Neurofibromatosis type 2 is an autosomal-dominant multiple neoplasia syndrome that results from mutations in the NF2 tumour suppressor gene located on chromosome 22q. It has a frequency of one inExpand
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Long-term outcome after resection of brainstem hemangioblastomas in von Hippel-Lindau disease.
OBJECT Brainstem hemangioblastomas are frequently encountered in patients with von Hippel-Lindau (VHL) disease. These tumors can cause significant morbidity, and their optimal management has not beenExpand
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Effect of pregnancy on hemangioblastoma development and progression in von Hippel-Lindau disease.
OBJECT Prior cases suggest that pregnancy increases the development and progression of CNS hemangioblastomas and/or peritumoral cysts. To determine the effect of pregnancy on CNS hemangioblastomasExpand
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