Ashok Patowary

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Autism spectrum disorders (ASDs) are a group of neurodevelopmental disorders, characterized by impairment in communication and social interactions, and by repetitive behaviors. ASDs are highly heritable, and estimates of the number of risk loci range from hundreds to >1000. We considered 7 extended families (size 12–47 individuals), each with ≥3 individuals(More)
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder often accompanied by intellectual disability, language impairment and medical co-morbidities. The heritability of autism is high and multiple genes have been implicated as causal. However, most of these genes have been identified in de novo cases. To further the understanding of(More)
This paper presents estimation of reliability R P(X Y)   of a system, for the cases when its strength (X) and stress (Y) follow exponential, normal or gamma distributions, using Monte Carlo simulation (MCS). First the parameters of strength and / stress are estimated and substituting them in the reliability expressions, in different cases, the estimates(More)
Autism is a complex genetic disorder where both de-novo and inherited genetics factors play a role. Next generation sequencing approaches have been extensively used to identify rare variants associated with autism. To date, all such studies were focused on nuclear genome; thereby leaving the role of mitochondrial DNA (mtDNA) variation in autism unexplored.(More)
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