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Mitochondrial Localization and Putative Signaling Function of Sucrose Synthase in Maize*
TLDR
It is reported that maize sucrose synthase (SUS) is distributed in organelles not involved in sucrose metabolism and may have novel roles beyond sucrose degradation, and co-immunoprecipitation studies indicate that SUS interacts with the voltage-dependent anion channel in an isoform-specific and anoxia-enhanced manner and may be involved in the regulation of solute fluxes into and out of mitochondria.
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PromoterPredict: sequence-based modelling of Escherichia coli σ70 promoter strength yields logarithmic dependence between promoter strength and sequence
TLDR
Using a well-characterized set of promoters, a multivariate linear regression model is trained and it is found that the log of the promoter strength is significantly linearly associated with a weighted sum of the –10 and –35 sequence profile scores.
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Computational Identification of Novel Stage-Specific Biomarkers in Colorectal Cancer Progression
TLDR
This study conducted a stage-based meta-analysis of the voluminous tumor genome-sequencing data and mined using multiple approaches for novel genes driving the progression to stage-II, stage-III and stage-IV colorectal cancer.
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Novel significant stage-specific differentially expressed genes in hepatocellular carcinoma
TLDR
This study identified novel significant stage-specific differentially expressed genes which could enhance the understanding of the molecular determinants of hepatocellular carcinoma progression and could serve as biomarkers that potentially underpin diagnosis as well as pinpoint therapeutic targets.
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Fourier Analysis of Conservation Patterns in Protein Secondary Structure
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Riboflow: using deep learning to classify riboswitches with ~99% accuracy
TLDR
The bidirectional LSTM RNN emerged as the best-performing learning method for identifying the ligand-specificity of riboswitches with an accuracy > 0.99 and macro-averaged F-score of 0.96.
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Riboflow: Using Deep Learning to Classify Riboswitches With ∼99% Accuracy
TLDR
This work would enable the design of genetic circuits with custom-tuned riboswitch aptamers that would effect precise translational control in synthetic biology and genome annotation, synthetic biology, and biotechnology workflows.
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Stage-differentiated ensemble modeling of DNA methylation landscapes uncovers salient biomarkers and prognostic signatures in colorectal cancer progression
TLDR
A comprehensive computational framework for stage-differentiated epigenomic analysis of colorectal cancer progression is developed, and several stage-salient diagnostic biomarkers, and an early-stage prognostic biomarker panel are identified.
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End-to-end computational approach to the design of RNA biosensors for detecting miRNA biomarkers of cervical cancer
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Evolutionary Analysis of Biological Excitability
TLDR
This work investigates the investigation of the complement of potassium ion channels in the genome and its generalizabilty, and an array of issues relevant to excitability is addressed, and a range of engagement in questions regarding the unity of life is proffered.
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