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Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update
TLDR
This present review article provides a recent update regarding epidemiology, pathogenesis, and molecular genetics of gallbladder cancer from published literature from online search engine PubMed.
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“Down syndrome: an insight of the disease”
TLDR
The genes or miRNA involved in Down syndrome associated Alzheimer’s disease, congenital heart defects (AVSD), leukemia including AMKL and ALL, hypertension and Hirschprung disease are discussed in this article.
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Purine biosynthetic pathway genes and methotrexate response in rheumatoid arthritis patients among north Indians
TLDR
Genes from all the three pathways seem to contribute to MTX response in the Indian population, however, these observations need to be replicated in an independent sample set.
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Haemorrhagic complications of pancreaticoduodenectomy
TLDR
An analysis of patients with post‐PD bleed is reported to identify predictors of bleed, predictor of survival following bleed and the management of post-PD bleed.
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Significant association between toll‐like receptor gene polymorphisms and gallbladder cancer
TLDR
The present study was undertaken to examine the potential association of two polymorphisms in TLR2 and TLR4 genes with gallbladder cancer (GBC) susceptibility.
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Interaction of genes from influx-metabolism-efflux pathway and their influence on methotrexate efficacy in rheumatoid arthritis patients among Indians
TLDR
Interactions between genes coding for deconjugation and transporter seem to be important determinants of MTX response in RA but replication and functional studies would be confirmatory.
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Evaluation of desmoglein enzyme‐linked immunosorbent assay (ELISA) in Indian patients with pemphigus vulgaris
TLDR
The role of the enzyme‐linked immunosorbent assay (ELISA) in the diagnosis of pemphigus vulgaris, and its correlation with disease severity and clinical presentation, is evaluated.
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Functional polymorphisms of the cyclooxygenase (PTGS2) gene and risk for gallbladder cancer in a North Indian population
TLDR
An association of PTGS2 −1195G>A polymorphism with gallbladder cancer, particularly in patients without gallstones, suggests a direct role of PT GS2 in cancer development.
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Management of Complicated Choledochal Cysts
TLDR
Complicated CDCs merit a carefully planned management strategy including percutaneous, endoscopic and surgical procedures, and the outcome depends on the nature of complication and the management strategy adopted.
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CYP17 polymorphism (rs743572) is associated with increased risk of gallbladder cancer in tobacco users
TLDR
CYP17 rs743572 is associated with increased risk of GBC in tobacco users in the North Indian population, however, the study requires confirmation in other populations.
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