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Cytochrome P450 2D6 (CYP2D6), an important CYP isoform with regard to drug-drug interactions, accounts for the metabolism of approximately 30% of all medications. To date, few studies have assessed the effects of botanical supplementation on human CYP2D6 activity in vivo. Six botanical extracts were evaluated in three separate studies (two extracts per(More)
This study examined differences in intensity and direction of symptoms of competitive state anxiety in high and low competitive subjects from the sports of rugby union, basketball, soccer, and field hockey. The 69 men were dichotomized via a median-split into high and low competitive groups based on their scores on the Sport Orientation Questionnaire. All(More)
The effects of goldenseal (Hydrastis canadensis) and kava kava (Piper methysticum) supplementation on human CYP3A activity were evaluated using midazolam (MDZ) as a phenotypic probe. Sixteen healthy volunteers were randomly assigned to receive either goldenseal or kava kava for 14 days. Each supplementation phase was followed by a 30-day washout period. MDZ(More)
Concomitant administration of botanical supplements with drugs that are P-glycoprotein (P-gp) substrates may produce clinically significant herb-drug interactions. This study evaluated the effects of St. John's wort and Echinacea on the pharmacokinetics of digoxin, a recognized P-gp substrate. Eighteen healthy volunteers were randomly assigned to receive a(More)
This study examined relationships between intensity and direction dimensions of competitive state anxiety, and also relationships with beam performance in a sample of female gymnasts. The 48 gymnasts, whose ages ranged from 14 to 16 years, competed in a beam competition and were divided, via the median split technique, into poor performance and good(More)
A theoretical tenet of 'goal perspective' theory that has received little research attention has been the nature of the relationship between the person and the environment with respect to predicting task and ego involvement in sport. This study therefore integrated both dispositional and situational criteria in order to examine their relative ability to(More)
This study reports a preliminary investigation of intensity and frequency of symptoms of competitive state anxiety. Forty-nine track and field athletes (27 males, 22 females) responded to a modified version of the Competitive State Anxiety Inventory-2 (CSAI-2) on four occasions during the period leading up to an important competition: 2 days, 1 day, 2 h and(More)
The sample consisted of 125 male inpatients admitted to one of two substance abuse treatment centers in Iowa. They were diagnosed by means of the Diagnostic Interview Schedule Screening Interview-Quick-DIS version, the Structural Interview for DSM-III-R Personality Disorder (PD), revised, and the Substance Abuse Reporting System. The most frequently(More)
Adverse drug events are largely considered to be errors in which the severity of effects could be lessened or even prevented through more effective medication reconciliation practices. Transitions of care, particularly at the time of discharge from the hospital, represent a time of heightened error vulnerability that contributes to medication discrepancy(More)
BACKGROUND AND OBJECTIVE Upgrades to electronic health record (EHR) systems scheduled to be introduced in the USA in 2014 will advance document interoperability between care providers. Specifically, the second stage of the federal incentive program for EHR adoption, known as Meaningful Use, requires use of the Consolidated Clinical Document Architecture(More)