Ashley R Longstreet

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2-Chloro-3-amino-4-picoline (CAPIC) is a strategic building block for the preparation of nevirapine, a widely-prescribed non-nucleosidic reverse transcriptase inhibitor for the treatment of HIV-infected patients. A continuous synthesis to the bromo derivative of a CAPIC intermediate, 2-bromo-4-methylnicotinonitrile, that terminates in a dead-end(More)
Herein, we demonstrate that a homogeneous catalyst can be prepared continuously via reaction with a packed-bed of a catalyst precursor. Specifically, we perform continuous proline catalyzed α-aminoxylations using a packed-bed of L-proline. The system relies on a multistep sequence in which an aldehyde and thiourea additive are passed through a column of(More)
Offered data on a variety of five-subtest WAIS short forms from which the clinician may select. All short forms were derived and cross-validated with a low socioeconomic status sample (N = 80). Data were reported on correlation of predicted and actual scores and on absolute accuracy of prediction. No significant difference in prediction was found across(More)
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