Ashley J. Wiese

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OBJECTIVE To determine the cardiorespiratory and anesthetic effects of 2, 6, and 20 mg kg(-1) IV alfaxalone in hydroxypropyl beta cyclodextrin (Alfaxan) in dogs. STUDY DESIGN Blinded four-way crossover randomized by dose. ANIMALS Eight healthy adult purpose-bred mixed breed dogs (four male, four female) weighing between 12 and 28 kg. METHODS Four (0,(More)
OBJECTIVE To determine the cardiorespiratory and anesthetic effects of 0, 5, 15, and 50 mg kg(-1) intravenous (IV) alfaxalone in hydroxypropyl beta cyclodextrin (Alfaxan; Jurox Pty Ltd, Rutherford, NSW, Australia) in cats. STUDY DESIGN Four treatments of alfaxalone were administered in sequential order. ANIMALS Eight healthy adult cats (four male; four(More)
OBJECTIVE To determine the effects of constant rate infusion of morphine, lidocaine, ketamine, and morphine-lidocaine-ketamine (MLK) combination on end-tidal isoflurane concentration (ET-Iso) and minimum alveolar concentration (MAC) in dogs anesthetized with isoflurane and monitor depth of anesthesia by use of the bispectral index (BIS). ANIMALS 6 adult(More)
We have developed a simple, cheap and efficient method of management of fingertip injury using a semi-occlusive dressing ("Opsite"--Smith and Nephew). The fingertip is covered with the "Opsite" once a week only. The dressing provides a temporary "skin", making the finger painless. This semi-occlusive "skin" allows the healing environment to reach an optimal(More)
Recently, we demonstrated that cholesterol gallstone-prone C57L/J mice rarely develop gallstones unless they are infected with certain cholelithogenic enterohepatic Helicobacter species. Because the common gastric pathogen H. pylori has been identified in the hepatobiliary tree of cholesterol gallstone patients, we wanted to ascertain if H. pylori is(More)
BACKGROUND Neurokinin-1 receptors (NK1-rs) located on superficial dorsal horn neurons are essential for integration of nociceptive input. Intrathecal injection of substance P-saporin (SP-SAP) leads to local loss of spinal NK1-r (+) neurons suggesting its potential as a therapeutic agent for chronic pain. The authors determined, in a canine model, effects of(More)
The quality and duration of anaesthesia, cardiorespiratory effects and recovery characteristics of a morphine, medetomidine, ketamine (MMK) drug combination were determined in cats. Six healthy, adult female cats were administered 0.2 mg/kg morphine sulphate, 60 microg/kg medetomidine hydrochloride, and 5 mg/kg ketamine hydrochloride intramuscularly.(More)
OBJECTIVE To compare the effects of lactated Ringer's solution (LRS) with those of a physiologically balanced 6% hetastarch plasma expander administered to isoflurane-anesthetized dogs with hypotension induced by blood withdrawal. ANIMALS 12 healthy Beagles. PROCEDURE Blood was withdrawn from isoflurane-anesthetized dogs (volume withdrawn measured) to a(More)
Serum zinc levels were estimated in different types of leprosy by means of the atomic absorption spectrophotometry method in 64 leprosy patients, comprising of tuberculoid tuberculoid (TT) (5), borderline tuberculoid (BT) (6), borderline borderline (BB) (10), borderline lepromatous (BL) (13), lepromatous lepromatous (LL) (14) and burnt-out leprosy (BO)(More)
OBJECTIVE To determine prevalence of pain among dogs and cats examined as outpatients at a veterinary teaching hospital and characteristics of pain in dogs and cats with evidence of pain. DESIGN Cross-sectional study. ANIMALS 1,153 dogs and 652 cats examined as outpatients at The Ohio State University during 2002. PROCEDURE A questionnaire was(More)