Ashley George

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NMDA receptors (NMDARs) mediate excitatory synaptic transmission during repetitive or prolonged glutamate release, playing a critical role in synaptic plasticity or cell death, respectively. Evidence indicates that a major pathway of NMDAR signaling to cell death in cortical and hippocampal neurons requires the scaffolding protein post-synaptic density 95(More)
I. INTRODUCTION Computational challenges in genomics data mining and analysis are an impending roadblock in modern health-sciences research, where algorithms for DNA sequence processing grow alarmingly in computational needs as datasets from new instruments continue to dramatically expand. Reconfigurable computers featuring customizable processing devices(More)
Highly polarized cells such as photoreceptors require precise and efficient strategies for establishing and maintaining the proper subcellular distribution of proteins. The signals and molecular machinery that regulate trafficking and sorting of synaptic proteins within cone inner segments is mostly unknown. In this study, we show that the(More)
This paper presents a novel hardware architecture using FPGA-based reconfigurable computing (RC) for accurate calculation of dense disparity maps in real-time, stereo-vision systems. Recent stereo-vision hardware solutions have proposed local-area approaches. Although parallelism can be easily exploited using local methods by replicating the window-based(More)
Network administration is a task that requires experience in relating symptoms of network problems with possible causes and corrective actions. We describe the design of a system and more specifically its information retrieval component, which aims to retrieve articles relevant to a given problem case from a collection of articles describing previously(More)
Netpal is a web-based dynamic knowledge base system designed to assist network administrators in their troubleshooting tasks, in recalling and storing experience, and in identifying new failure cases and their symptoms. In the context of web hosting environments, Netpal summarises network data and and supports retrieval of relevant organisational experience(More)
Genetic Programming offers freedom in the definition of the cost function that is unparalleled among supervised learning algorithms. However, this freedom goes largely unexploited in previous work. Here, we revisit the design of fitness functions for genetic programming by explicitly considering the contribution of the wrapper and cost function. Within the(More)
Abnormalities in the ability of cells to properly degrade proteins have been identified in many neurodegenerative diseases. Recent work has implicated synaptojanin 1 (SynJ1) in Alzheimer's disease and Parkinson's disease, although the role of this polyphosphoinositide phosphatase in protein degradation has not been thoroughly described. Here, we dissected(More)
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