Ashley C Brown

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Increased tissue stiffness and epithelial-to-mesenchymal transitions (EMTs) are two seemingly discrete hallmarks of fibrotic diseases. Despite recent findings highlighting the influence of tissue mechanical properties on cell phenotype, it remains unclear what role increased tissue stiffness has in the regulation of previously reported fibronectin-mediated(More)
Market coordination of transmission loading relief in an electric grid with multiple regions implies trading across boundaries. Starting with the early framework for transmission loading relief that relies primarily on administrative priorities, introduction of prices and explicit trading to redispatch across regions would provide market solutions for(More)
Efforts to create platelet-like structures for the augmentation of haemostasis have focused solely on recapitulating aspects of platelet adhesion; more complex platelet behaviours such as clot contraction are assumed to be inaccessible to synthetic systems. Here, we report the creation of fully synthetic platelet-like particles (PLPs) that augment clotting(More)
Cell interactions with their extracellular matrix (ECM) microenvironments play a major role in directing cellular processes that can drive wound healing and tissue regeneration but, if uncontrolled, lead to pathological progression. One such process, epithelial to mesenchymal transition (EMT), if finely controlled could have significant potential in(More)
We present a microfluidic cell culture array with unique versatility and parallelization for experimental trials requiring perfusion cultures. Specifically, we realize a rectangular chamber array in a PDMS device with three attributes: (i) continuous perfusion; (ii) flow paths that forbid cross-chamber contamination; and (iii) chamber shielding from direct(More)
Wound healing is a complex, dynamic process required for maintaining homeostasis in an organism. Along with being controlled biochemically, wound healing is also controlled through the transduction of biophysical stimuli through cell interactions with the extracellular matrix (ECM). This review provides an overview of the ECM's role in the wound healing(More)
Although a great deal of emphasis has been put on it, privatization of infrastructure is only a means to an end, and not an end in and of itself. The goal is a more efficient sector delivering quality service while fulfilling its social responsibilities. Privatization is only an effective means towards the achievement of that result if it is done in the(More)
Advance scheduling of electricity markets could create a conflict between reliability requirements and market operations. Unlike the case for the real-time market alone, an independent system operator charged with preserving system reliability may face a new computational challenge in balancing the requirements of markets and system security. A bid-based,(More)
Under the predominant existing paradigm, in balancing the public interest in transmission line planning and siting decisions most state regulatory authorities weigh the benefits to the customers of a specific utility system, or to the consumers in an individual state, against potential adverse consequences. This approach to transmission siting was designed(More)
Efforts to create platelet-like structures for the augmentation of hemostasis have focused solely on recapitulating aspects of platelet adhesion 1; more complex platelet behaviors such as clot contraction 2 are assumed to be inaccessible to synthetic systems. Here, we report the creation of fully synthetic platelet-like particles (PLPs) that augment(More)