Ashley Brenton

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OBJECTIVE Pain levels are a key metric in clinical care. However, the assessment of pain is limited to basic questionnaires and physician interpretation, which yield subjective data. Genetic markers of pain sensitivity, such as single nucleotide polymorphisms in the catechol-O-methyltransferase gene, have been shown to be associated with pain perception and(More)
BACKGROUND Opioid abuse in chronic pain patients is a major public health issue, with rapidly increasing addiction rates and deaths from unintentional overdose more than quadrupling since 1999. PURPOSE This study seeks to determine the predictability of aberrant behavior to opioids using a comprehensive scoring algorithm incorporating phenotypic risk(More)
BACKGROUND Precision medicine is a promising technology in patient care that combines genetic analysis with clinical data, such as health, behavioral, functional, environment, and lifestyle information. Here we present the case of a 54-year old woman who, following an accident, had uncontrolled chronic pain and was subsequently labeled a drug seeker. CASE(More)
A prospective, longitudinal study was conducted to determine the clinical utility of an algorithm-based precision medicine profile designed to assess risk associated with opioid use disorder in 5,315 patients in a clinical setting. Specifically, we sought to assess how physicians were using the profile and how its use affected patient outcomes. Ninety(More)
Fifteen children aged 9 to 15 months, who were on the observation register of a city, and considered to be showing signs of delayed development, were studied over a 3-month period. Following assessment, the parents were shown ways in which they could train their children appropriate to their development levels, in separate fields of locomotion, social(More)
BACKGROUND Opioid abuse in chronic pain patients is a major public health issue. Primary care providers are frequently the first to prescribe opioids to patients suffering from pain, yet do not always have the time or resources to adequately evaluate the risk of opioid use disorder (OUD). PURPOSE This study seeks to determine the predictability of(More)
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