Ashley B. Pitcher

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We consider an optimal control problem based on the evolutionary game theory model introduced by Short et al. Cooperation and punishment in an adversarial game: How defectors pave the way to a peaceful society. Cooperation and punishment in an adversarial game: How defectors pave the way to a peaceful society. Phys. Rev. E 82(6), 066114.1–066114.7) it is(More)
In most developed countries, HCV is primarily transmitted by injecting drug users (IDUs). HCV antiviral treatment is effective, and deemed cost-effective for those with no re-infection risk. However, few active IDUs are currently treated. Previous modelling studies have shown antiviral treatment for active IDUs could reduce HCV prevalence, and there is(More)
The lack of head-to-head clinical studies powered to compare atomoxetine and osmotic release oral system (OROS) methylphenidate necessitates treatment comparison by methods that include indirect evidence such as network meta-analysis (NMA). A NMA assessing the relative treatment effects of atomoxetine and OROS methylphenidate in adults with(More)
Quasipolynomials arise in a number of applications, and in particular as the characteristic equation associated with systems of delay differential equations. Quasipolynomial equations are generally difficult to solve, and most often must be solved numerically. In the non-trivial case, quasipolynomials have an infinite number of roots in the complex plane.(More)
BACKGROUND No study has compared the cost-effectiveness of active treatment options for unresectable or metastatic gastrointestinal stromal tumours in patients who progressed on or are intolerant to prior treatment with imatinib and sunitinib. The aim of this study was to estimate the cost-effectiveness of regorafenib compared to imatinib rechallenge in(More)
OBJECTIVE To assess the cost-effectiveness of subcutaneous interferon (sc IFN) beta-1a 44 mcg 3-times weekly (tiw) vs no treatment at reducing the risk of conversion to multiple sclerosis (MS) in patients with clinically isolated syndrome (CIS) in Sweden. METHODS A Markov model was constructed to simulate the clinical course of patients with CIS treated(More)