Ashleigh Goethel

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Inflammatory bowel disease (IBD) is an abnormal inflammatory response within the gut to a trigger that has yet to be identified. The family history in many patients, especially those with Crohn's disease, suggests a genetic predisposition. It has been hypothesized that the abnormal inflammatory response is due in part to genetic alterations in the normal(More)
BACKGROUND & AIMS New therapeutic approaches are needed for inflammatory bowel diseases. A monoclonal antibody against CD3 (anti-CD3) suppresses T-cell-mediated autoimmune diseases such as experimental allergic encephalomyelitis. We explored the effects of anti-CD3 in mice with colitis. METHODS Severe combined immunodeficient mice were given injections of(More)
Although the etiology of Crohn's disease (CD) remains elusive this disease is characterized by T cell activation that leads to chronic inflammation and mucosal damage. A potential role for maladaptation between the intestinal microbiota and the mucosal immune response is suggested by the fact that mutations in the pattern recognition receptor Nod2 are(More)
Loss of function in the NOD2 gene is associated with a higher risk of developing Crohn's disease (CD). CD is characterized by activation of T cells and activated T cells are involved in mucosal inflammation and mucosal damage. We found that acute T cell activation with anti-CD3 mAb induced stronger small intestinal mucosal damage in NOD2(-/-) mice compared(More)
Determinants of Intestinal Permeability in Healthy First Degree Relatives of Crohn’s Disease Patients, W. Turpin, D. Kevans, K. Shestopaloff, M. Smith, D. Guttman, M. Silverberg, W. Xu, A. Paterson, and K. Croitoru University of Toronto, Toronto, ON, Canada Mount Sinai Hospital, Toronto, ON, Canada Dalla Lana School of Public Health, Toronto, ON, Canada(More)
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