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  • Christine E Arris, Frank T. Boyle, +15 authors Wy Yu
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2000 (First Published: 1 July 2000)
  • Substituted guanines and pyrimidines were tested as inhibitors of cyclin B1/CDK1 and cyclin A3/CDK2 and soaked into crystals of monomeric CDK2. O6-Cyclohexylmethylguanine (NU2058) was a competitiveContinue Reading
  • Ian Robert Hardcastle, Christine E Arris, +15 authors Hayley J. Whitfield
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2004 (First Published: 1 July 2004)
  • The adenosine 5'-triphosphate (ATP) competitive cyclin-dependent kinase inhibitor O(6)-cyclohexylmethylguanine (NU2058, 1) has been employed as the lead in a structure-based drug discovery programContinue Reading
  • Ashleigh E. Gibson, Christine E Arris, +14 authors Hayley J. Whitfield
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2002 (First Published: 1 August 2002)
  • O(6)-substituted guanines are adenosine 5'-triphosphate (ATP) competitive inhibitors of CDK1/cyclin B1 and CDK2/cyclin A, the O(6) substituent occupying the kinase ribose binding site. Fifty-eightContinue Reading
  • Michelle A. Shipman, Clayton Price, Ashleigh E. Gibson, Mark R J Elsegood, William Clegg, Andrew Houlton
  • Chemistry, Medicine
  • Chemistry
  • 2000 (First Published: 1 December 2000)
  • A series of ZnII and CdII complexes of adenine and guanine derivatives containing a diamine tether have been isolated from aqueous solutions and characterised by single crystal X-ray analysis. TheseContinue Reading