Ashish Vijay Jain

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OBJECTIVE To demonstrate the efficacy, tolerability, and safety of acarbose compared with placebo in patients with type 2 diabetes inadequately controlled with diet and metformin (2,000 or 2,500 mg/day in divided doses). RESEARCH DESIGN AND METHODS This study had a multicenter randomized double-blind placebo-controlled parallel-group comparison design.(More)
Male rats (10 rats/group) were treated with phenobarbital (PB), phenylbutazone (PBZ), stanozolol (3 inducers of cytochrome P450-dependent enzymes), piperonyl butoxide (PBO; a P450 inhibitor), cobaltous chloride (CoCl2; an inhibitor of hemoprotein synthesis), 5,6-benzoflavone (BNF; an inducer of cytochrome P448 dependent enzymes), cysteine [CYS; a(More)
Groups of 8 male crossbreed domestic goats were given 3 dosage levels of aflatoxin B1 [(AFB1) mg/kg of body weight/day] orally: 0.1 for 34 days; 0.2 for 18 days; or 0.4 for 10 days. Clinical condition, feed consumption, and selected blood values were determined. Clinical signs of toxicosis included decreased feed consumption, slight-to-moderate loss of body(More)
A 4-month-old Pomeranian pup was examined because of anorexia, salivation, and persistent vomiting. Initial laboratory testing revealed marked hemolytic anemia with spherocytosis. Survey abdominal radiography revealed 4 metal objects which, when removed by gastrotomy, were identified as pennies. Of 4 pennies, 3 were minted since 1983 and were heavily pitted(More)
Pseudohyperchloremia and a negative anion gap were detected in goats with bromide intoxication. Bromide interferes with ion-specific electrodes, resulting in a falsely increased serum chloride concentrations. Bromide intoxication should be considered in animals with progressive neurologic signs, a high serum chloride value, and a low or negative anion gap.
To compare the protective potencies of a large number of known and potential cyanide antagonists in one stock of mice, groups (N = 10) of male CF-1 Swiss-Webster mice were given a single maximal or near-maximal intraperitoneal injection of each substance. Ethyl maleate, a glutathione (GSH) depletor and potential enhancer of cyanide toxicity, was given to(More)
OBJECTIVE This study compared the efficacy and tolerability of two combination regimens of valsartan and hydrochlorothiazide (HCTZ) with valsartan monotherapy in patients with essential hypertension inadequately controlled with valsartan 80mg once daily. PATIENTS AND METHODS A total of 708 patients with inadequately controlled blood pressure after 4(More)
Pathologic changes and serum electrophoretic patterns were determined in 30 male goats given aflatoxin B1 (AFB1) orally at 4 dosage levels (mg/kg of body weight/day): 0.1 for 34 days; 0.2 for 18 days; 0.4 for 10 days; or 0.0 for 29 days. Goats given AFB1 had increased mean concentrations of gamma-globulins and most had decreased mean concentrations of(More)