Ashish Gupta

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BACKGROUND Mosquitoes transmit serious human diseases, causing millions of deaths every year. Use of synthetic insecticides to control vector mosquitoes has caused physiological resistance and adverse environmental effects in addition to high operational cost. Insecticides of botanical origin have been reported as useful for control of mosquitoes.(More)
The interleukin-10 knockout mouse (IL10tm/tm) has been proposed as a model for human frailty, a geriatric syndrome characterized by skeletal muscle (SM) weakness, because it develops an age-related decline in SM strength compared to control (C57BL/6J) mice. Compromised energy metabolism and energy deprivation appear to play a central role in muscle weakness(More)
Cognitive psychologists have long recognized that the acquisition of a motor skill involves a transition from attention-demanding controlled processing to more fluent automatic processing. Neurosci-entific studies suggest that controlled and automatic processing rely on two largely distinct neural pathways. The controlled pathway, which includes the(More)
Doxorubicin (DOX) is a commonly used life-saving antineoplastic agent that also causes dose-dependent cardiotoxicity. Because ATP is absolutely required to sustain normal cardiac contractile function and because impaired ATP synthesis through creatine kinase (CK), the primary myocardial energy reserve reaction, may contribute to contractile dysfunction in(More)
Traditional artificial neural network models of learning suffer from catastrophic interference. They are commonly trained to perform only one specific task, and when trained on a new task, they forget the original task completely. It has been shown that the foundational neu-rocomputational principles embodied by the Leabra cognitive modeling framework are(More)
Magnetic resonance imaging (MRI) has emerged as a powerful and reliable tool to noninvasively study the cardiovascular system in clinical practice. Because transgenic mouse models have assumed a critical role in cardiovascular research, technological advances in MRI have been extended to mice over the last decade. These have provided critical insights into(More)
In this study we introduce a rescoring method to improve the accuracy of docking programs against mPGES-1. The rescoring method developed is a result of extensive computational study in which different scoring functions and molecular descriptors were combined to develop consensus and rescoring methods. 127 mPGES-1 inhibitors were collected from literature(More)
CONTEXT Dental evidence is a valuable tool in identifying individuals, especially when disasters befall. Reference points in faciomaxillary region such as interpupillary distance, intercanthal distance, interalar distance and bizygomatic width can significantly contribute toward reconstruction of two-dimensional (2D) facial profiles. This study was(More)
OBJECTIVE To compare the helical and axial modes of indirect computed tomographic (CT) venography (CTV) for accuracy for diagnosing deep venous thrombosis (DVT) of the lower extremities as well as for their radiation burden in patients proven to have pulmonary thromboembolism (PTE) on CT pulmonary angiography (CTPA). SUBJECTS AND METHODS Of patients(More)