Ashish A. Kulkarni

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Nanomedicines that preferentially deploy cytotoxic agents to tumors and molecular targeted therapeutics that inhibit specific aberrant oncogenic drivers are emerging as the new paradigm for the management of cancer. While combination therapies are a mainstay of cancer chemotherapy, few studies have addressed the combination of nanomedicines and molecular(More)
Metastasis is a major cause of mortality and remains a hurdle in the search for a cure for cancer. Not much is known about metastatic cancer cells and endothelial cross-talk, which occurs at multiple stages during metastasis. Here we report a dynamic regulation of the endothelium by cancer cells through the formation of nanoscale intercellular membrane(More)
The centrality of phosphoinositide-3-kinase (PI3K) in cancer etiology is well established, but clinical translation of PI3K inhibitors has been limited by feedback signaling, suboptimal intratumoral concentration, and an insulin resistance "class effect." This study was designed to explore the use of supramolecular nanochemistry for targeting PI3K to(More)
Pr ecis: The prevalent cancer-cell oriented view of carcinogenesis risk neglects the important contribution of population-level interactions during tumor progression as vital modulators of that risk. Pr ecis: These findings are important because they establish a causal link between hypoxia and tumor escape from T cell–mediated immunity, and they open new(More)
Nanomedicines that preferentially deploy cytotoxic agents to tumors and molecular targeted therapeutics that inhibit specific aberrant oncogenic drivers are emerging as the new paradigm for the management of cancer. While combination therapies are a mainstay of cancer chemotherapy, few studies have addressed the combination of nanomedicines and molecular(More)
This system capitalizes on the fact that the complex event scenarios in an industry are repetitive in nature. It abstracts these scenarios into reusable templates with configurable parameters. This is an advantage that the system brings over the existing Complex Event Processing tools. These tools provide the capability of defining complex event scenarios(More)
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